1bl3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1bl3.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1bl3.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1bl3| PDB=1bl3 | SCENE= }}
{{STRUCTURE_1bl3| PDB=1bl3 | SCENE= }}
-
'''CATALYTIC DOMAIN OF HIV-1 INTEGRASE'''
+
===CATALYTIC DOMAIN OF HIV-1 INTEGRASE===
-
==Overview==
+
<!--
-
Human immunodeficiency virus (HIV) integrase is the enzyme responsible for insertion of a DNA copy of the viral genome into host DNA, an essential step in the replication cycle of HIV. HIV-1 integrase comprises three functional and structural domains: an N-terminal zinc-binding domain, a catalytic core domain and a C-terminal DNA-binding domain. The catalytic core domain with the F185H mutation has been crystallized without sodium cacodylate in a new crystal form, free and complexed with the catalytic metal Mg2+. The structures have been determined and refined to about 2.2 A. Unlike the previously reported structures, the three active-site carboxylate residues (D,D-35-E motif) are well ordered and both aspartate residues delineate a proper metal-binding site. Comparison of the active binding site of this domain with that of other members from the polynucleotidyl transferases superfamily shows a high level of similarity, providing a confident template for the design of antiviral agents.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9735293}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9735293 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9735293}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Polynucleotidyl transferase]]
[[Category: Polynucleotidyl transferase]]
[[Category: Polyprotein]]
[[Category: Polyprotein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:39:12 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:19:47 2008''

Revision as of 16:19, 30 June 2008

Image:1bl3.png

Template:STRUCTURE 1bl3

CATALYTIC DOMAIN OF HIV-1 INTEGRASE

Template:ABSTRACT PUBMED 9735293

About this Structure

1BL3 is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases., Maignan S, Guilloteau JP, Zhou-Liu Q, Clement-Mella C, Mikol V, J Mol Biol. 1998 Sep 18;282(2):359-68. PMID:9735293

Page seeded by OCA on Mon Jun 30 19:19:47 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bl3"
Personal tools