1blx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1blx.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1blx.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1blx| PDB=1blx | SCENE= }}
{{STRUCTURE_1blx| PDB=1blx | SCENE= }}
-
'''P19INK4D/CDK6 COMPLEX'''
+
===P19INK4D/CDK6 COMPLEX===
-
==Overview==
+
<!--
-
The crystal structure of the cyclin D-dependent kinase Cdk6 bound to the p19 INK4d protein has been determined at 1.9 A resolution. The results provide the first structural information for a cyclin D-dependent protein kinase and show how the INK4 family of CDK inhibitors bind. The structure indicates that the conformational changes induced by p19INK4d inhibit both productive binding of ATP and the cyclin-induced rearrangement of the kinase from an inactive to an active conformation. The structure also shows how binding of an INK4 inhibitor would prevent binding of p27Kip1, resulting in its redistribution to other CDKs. Identification of the critical residues involved in the interaction explains how mutations in Cdk4 and p16INK4a result in loss of kinase inhibition and cancer.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9751051}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9751051 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9751051}}
==About this Structure==
==About this Structure==
Line 41: Line 45:
[[Category: Cyclin-dependent kinase]]
[[Category: Cyclin-dependent kinase]]
[[Category: Inhibitor protein]]
[[Category: Inhibitor protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:40:54 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:21:48 2008''

Revision as of 16:21, 30 June 2008

Image:1blx.png

Template:STRUCTURE 1blx

P19INK4D/CDK6 COMPLEX

Template:ABSTRACT PUBMED 9751051

About this Structure

1BLX is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d., Brotherton DH, Dhanaraj V, Wick S, Brizuela L, Domaille PJ, Volyanik E, Xu X, Parisini E, Smith BO, Archer SJ, Serrano M, Brenner SL, Blundell TL, Laue ED, Nature. 1998 Sep 17;395(6699):244-50. PMID:9751051

Page seeded by OCA on Mon Jun 30 19:21:48 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1blx"
Personal tools