1bm0

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{{STRUCTURE_1bm0| PDB=1bm0 | SCENE= }}
{{STRUCTURE_1bm0| PDB=1bm0 | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN'''
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===CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN===
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==Overview==
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A new triclinic crystal form of human serum albumin (HSA), derived either from pool plasma (pHSA) or from a Pichia pastoris expression system (rHSA), was obtained from polyethylene glycol 4000 solution. Three-dimensional structures of pHSA and rHSA were determined at 2.5 A resolution from the new triclinic crystal form by molecular replacement, using atomic coordinates derived from a multiple isomorphous replacement work with a known tetragonal crystal form. The structures of pHSA and rHSA are virtually identical, with an r.m. s. deviation of 0.24 A for all Calpha atoms. The two HSA molecules involved in the asymmetric unit are related by a strict local twofold symmetry such that the Calpha atoms of the two molecules can be superimposed with an r.m.s. deviation of 0.28 A in pHSA. Cys34 is the only cysteine with a free sulfhydryl group which does not participate in a disulfide linkage with any external ligand. Domains II and III both have a pocket formed mostly of hydrophobic and positively charged residues and in which a very wide range of compounds may be accommodated. Three tentative binding sites for long-chain fatty acids, each with different surroundings, are located at the surface of each domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 10388840 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10388840}}
==About this Structure==
==About this Structure==
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[[Category: Albumin]]
[[Category: Albumin]]
[[Category: Carrier protein]]
[[Category: Carrier protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:41:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:21:57 2008''

Revision as of 16:21, 30 June 2008

Image:1bm0.png


PDB ID 1bm0

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1bm0, resolution 2.50Å ()
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN

Template:ABSTRACT PUBMED 10388840

About this Structure

1BM0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human serum albumin at 2.5 A resolution., Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K, Protein Eng. 1999 Jun;12(6):439-46. PMID:10388840

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