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1bm8

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{{STRUCTURE_1bm8| PDB=1bm8 | SCENE= }}
{{STRUCTURE_1bm8| PDB=1bm8 | SCENE= }}
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'''DNA-BINDING DOMAIN OF MBP1'''
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===DNA-BINDING DOMAIN OF MBP1===
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==Overview==
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BACKGROUND: During the cell cycle, cells progress through four distinct phases, G1, S, G2 and M; transcriptional controls play an important role at the transition between these phases. MCB-binding factor (MBF), a transcription factor from budding yeast, binds to the so-called MCB (MluI cell-cycle box) elements found in the promoters of many DNA synthesis genes, and activates the transcription of those at the G1--&gt;S phase transition. MBF is comprised of two proteins, Mbp1 and Swi6. RESULTS: The three-dimensional structure of the N-terminal DNA-binding domain of Mbp1 has been determined by multiwavelength anomalous diffraction from crystals of the selenomethionyl variant of the protein. The structure is composed of a six-stranded beta sheet interspersed with two pairs of alpha helices. The most conserved core region among Mbp1-related transcription factors folds into a central helix-turn-helix motif with a short N-terminal beta strand and a C-terminal beta hairpin. CONCLUSIONS: Despite little sequence similarity, the structure within the core region of the Mbp1 N-terminal domain exhibits a similar fold to that of the DNA-binding domains of other proteins, such as hepatocyte nuclear factor-3gamma and histone H5 from eukaryotes, and the prokaryotic catabolite gene activator. However, the structure outside the core region defines Mbp1 as a larger entity with substructures that stabilize and display the helix-turn-helix motif.
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(as it appears on PubMed at http://www.pubmed.gov), where 9083114 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9083114}}
==About this Structure==
==About this Structure==
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[[Category: Multiwavelength anomalous diffraction]]
[[Category: Multiwavelength anomalous diffraction]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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Revision as of 16:22, 30 June 2008

Image:1bm8.png

Template:STRUCTURE 1bm8

DNA-BINDING DOMAIN OF MBP1

Template:ABSTRACT PUBMED 9083114

About this Structure

1BM8 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of the DNA-binding domain of Mbp1, a transcription factor important in cell-cycle control of DNA synthesis., Xu RM, Koch C, Liu Y, Horton JR, Knapp D, Nasmyth K, Cheng X, Structure. 1997 Mar 15;5(3):349-58. PMID:9083114

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