1bml

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[[Image:1bml.gif|left|200px]]
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{{Seed}}
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[[Image:1bml.png|left|200px]]
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{{STRUCTURE_1bml| PDB=1bml | SCENE= }}
{{STRUCTURE_1bml| PDB=1bml | SCENE= }}
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'''COMPLEX OF THE CATALYTIC DOMAIN OF HUMAN PLASMIN AND STREPTOKINASE'''
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===COMPLEX OF THE CATALYTIC DOMAIN OF HUMAN PLASMIN AND STREPTOKINASE===
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==Overview==
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Streptokinase is a plasminogen activator widely used in treating blood-clotting disorders. Complexes of streptokinase with human plasminogen can hydrolytically activate other plasminogen molecules to plasmin, which then dissolves blood clots. A similar binding activation mechanism also occurs in some key steps of blood coagulation. The crystal structure of streptokinase complexed with the catalytic unit of human plasmin was solved at 2.9 angstroms. The amino-terminal domain of streptokinase in the complex is hypothesized to enhance the substrate recognition. The carboxyl-terminal domain of streptokinase, which binds near the activation loop of plasminogen, is likely responsible for the contact activation of plasminogen in the complex.
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The line below this paragraph, {{ABSTRACT_PUBMED_9733510}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9733510 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9733510}}
==About this Structure==
==About this Structure==
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[[Category: Human plasmin]]
[[Category: Human plasmin]]
[[Category: Streptokinase]]
[[Category: Streptokinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:42:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:23:15 2008''

Revision as of 16:23, 30 June 2008

Image:1bml.png

Template:STRUCTURE 1bml

COMPLEX OF THE CATALYTIC DOMAIN OF HUMAN PLASMIN AND STREPTOKINASE

Template:ABSTRACT PUBMED 9733510

About this Structure

1BML is a Protein complex structure of sequences from Homo sapiens and Streptococcus dysgalactiae subsp. equisimilis. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domain of human plasmin complexed with streptokinase., Wang X, Lin X, Loy JA, Tang J, Zhang XC, Science. 1998 Sep 11;281(5383):1662-5. PMID:9733510

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