1bmp

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[[Image:1bmp.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1bmp| PDB=1bmp | SCENE= }}
{{STRUCTURE_1bmp| PDB=1bmp | SCENE= }}
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'''BONE MORPHOGENETIC PROTEIN-7'''
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===BONE MORPHOGENETIC PROTEIN-7===
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==Overview==
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We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a member of the transforming growth factor beta (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily. We find that although there is limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing the OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors.
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(as it appears on PubMed at http://www.pubmed.gov), where 8570652 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8570652}}
==About this Structure==
==About this Structure==
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[[Category: Morphogen]]
[[Category: Morphogen]]
[[Category: Transforming growth factor]]
[[Category: Transforming growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:42:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:23:35 2008''

Revision as of 16:23, 30 June 2008

Image:1bmp.png

Template:STRUCTURE 1bmp

BONE MORPHOGENETIC PROTEIN-7

Template:ABSTRACT PUBMED 8570652

About this Structure

1BMP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily., Griffith DL, Keck PC, Sampath TK, Rueger DC, Carlson WD, Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):878-83. PMID:8570652

Page seeded by OCA on Mon Jun 30 19:23:35 2008

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