1bnk

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[[Image:1bnk.gif|left|200px]]
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{{Seed}}
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[[Image:1bnk.png|left|200px]]
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{{STRUCTURE_1bnk| PDB=1bnk | SCENE= }}
{{STRUCTURE_1bnk| PDB=1bnk | SCENE= }}
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'''HUMAN 3-METHYLADENINE DNA GLYCOSYLASE COMPLEXED TO DNA'''
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===HUMAN 3-METHYLADENINE DNA GLYCOSYLASE COMPLEXED TO DNA===
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==Overview==
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DNA N-glycosylases are base excision-repair proteins that locate and cleave damaged bases from DNA as the first step in restoring the genetic blueprint. The human enzyme 3-methyladenine DNA glycosylase removes a diverse group of damaged bases from DNA, including cytotoxic and mutagenic alkylation adducts of purines. We report the crystal structure of human 3-methyladenine DNA glycosylase complexed to a mechanism-based pyrrolidine inhibitor. The enzyme has intercalated into the minor groove of DNA, causing the abasic pyrrolidine nucleotide to flip into the enzyme active site, where a bound water is poised for nucleophilic attack. The structure shows an elegant means of exposing a nucleotide for base excision as well as a network of residues that could catalyze the in-line displacement of a damaged base from the phosphodeoxyribose backbone.
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The line below this paragraph, {{ABSTRACT_PUBMED_9790531}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9790531 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9790531}}
==About this Structure==
==About this Structure==
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[[Category: Dna glycosylase]]
[[Category: Dna glycosylase]]
[[Category: Dna repair]]
[[Category: Dna repair]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:44:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:25:33 2008''

Revision as of 16:25, 30 June 2008

Image:1bnk.png

Template:STRUCTURE 1bnk

HUMAN 3-METHYLADENINE DNA GLYCOSYLASE COMPLEXED TO DNA

Template:ABSTRACT PUBMED 9790531

About this Structure

1BNK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision., Lau AY, Scharer OD, Samson L, Verdine GL, Ellenberger T, Cell. 1998 Oct 16;95(2):249-58. PMID:9790531

Page seeded by OCA on Mon Jun 30 19:25:33 2008

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