1bo0

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[[Image:1bo0.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1bo0| PDB=1bo0 | SCENE= }}
{{STRUCTURE_1bo0| PDB=1bo0 | SCENE= }}
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'''MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE'''
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===MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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1H-NMR spectroscopy and analytical ultracentrifugation studies reveal that monocyte chemoattractant protein-3 (MCP-3) is a monomer. NMR solution structure shows that MCP-3 adopts an alphabeta fold similar to what is observed in structures of other known chemokines. However, MCP-3 is unique in that it does not show a propensity to form dimers. The closely related chemokines MCP-1 and MCP-2 show a monomer-dimer equilibrium in sedimentation equilibrium studies (approximately 0.2-2 mg/ml). As these proteins are present at nanomolar concentrations in vivo, the results suggest that they are monomeric at functional concentrations and that the monomer is the functionally significant form of MCP-1, MCP-2 and MCP-3.
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The line below this paragraph, {{ABSTRACT_PUBMED_8898111}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8898111 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8898111}}
==About this Structure==
==About this Structure==
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1BO0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BO0 OCA].
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1BO0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BO0 OCA].
==Reference==
==Reference==
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[[Category: Sykes, B D.]]
[[Category: Sykes, B D.]]
[[Category: Chemotactic cytokine]]
[[Category: Chemotactic cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:45:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:26:32 2008''

Revision as of 16:26, 30 June 2008

Image:1bo0.png

Template:STRUCTURE 1bo0

MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 8898111

About this Structure

1BO0 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3., Kim KS, Rajarathnam K, Clark-Lewis I, Sykes BD, FEBS Lett. 1996 Oct 21;395(2-3):277-82. PMID:8898111

Page seeded by OCA on Mon Jun 30 19:26:32 2008

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