1bow

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[[Image:1bow.jpg|left|200px]]
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{{Seed}}
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[[Image:1bow.png|left|200px]]
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{{STRUCTURE_1bow| PDB=1bow | SCENE= }}
{{STRUCTURE_1bow| PDB=1bow | SCENE= }}
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'''MULTIDRUG-BINDING DOMAIN OF TRANSCRIPTION ACTIVATOR BMRR (APO FORM)'''
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===MULTIDRUG-BINDING DOMAIN OF TRANSCRIPTION ACTIVATOR BMRR (APO FORM)===
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==Overview==
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Multidrug-efflux transporters demonstrate an unusual ability to recognize multiple structurally dissimilar toxins. A comparable ability to bind diverse hydrophobic cationic drugs is characteristic of the Bacillus subtilis transcription regulator BmrR, which upon drug binding activates expression of the multidrug transporter Bmr. Crystal structures of the multidrug-binding domain of BmrR (2.7 A resolution) and of its complex with the drug tetraphenylphosphonium (2.8 A resolution) revealed a drug-induced unfolding and relocation of an alpha helix, which exposes an internal drug-binding pocket. Tetraphenylphosphonium binding is mediated by stacking and van der Waals contacts with multiple hydrophobic residues of the pocket and by an electrostatic interaction between the positively charged drug and a buried glutamate residue, which is the key to cation selectivity. Similar binding principles may be used by other multidrug-binding proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 10025401 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10025401}}
==About this Structure==
==About this Structure==
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[[Category: Multidrug binding]]
[[Category: Multidrug binding]]
[[Category: Transcription activator]]
[[Category: Transcription activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:46:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:28:42 2008''

Revision as of 16:28, 30 June 2008

Image:1bow.png

Template:STRUCTURE 1bow

MULTIDRUG-BINDING DOMAIN OF TRANSCRIPTION ACTIVATOR BMRR (APO FORM)

Template:ABSTRACT PUBMED 10025401

About this Structure

1BOW is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter., Zheleznova EE, Markham PN, Neyfakh AA, Brennan RG, Cell. 1999 Feb 5;96(3):353-62. PMID:10025401

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