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1boy

From Proteopedia

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[[Image:1boy.gif|left|200px]]
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{{Seed}}
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[[Image:1boy.png|left|200px]]
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{{STRUCTURE_1boy| PDB=1boy | SCENE= }}
{{STRUCTURE_1boy| PDB=1boy | SCENE= }}
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'''EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR'''
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===EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR===
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==Overview==
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Tissue factor is a cell-surface glycoprotein receptor which initiates the blood coagulation cascade after vessel injury by interacting with blood clotting factor VII/VIIa and which is implicated in various pathological processes. When bound to tissue factor, factor VII is readily converted to the active protease factor VIIa by trace amounts of factors Xa, IXa or VIIa. Human tissue factor consists of 263 residues, the first 219 of which comprise the extracellular region. We have determined the crystal structure of the extracellular region at a resolution of 2.2 A. Tissue factor consists of two immunoglobulin-like domains associated through an extensive, novel, interdomain interface region. The binding site for factor VII lies at the interface region and involves residues from domain 1 and an extended loop (binding 'finger') of domain 2. This is the first reported structure of a representative of the class 2 cytokine receptor family, which also includes interferon-alpha, interferon-gamma (refs 2, 3) and interleukin-10 (ref. 4) receptors.
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The line below this paragraph, {{ABSTRACT_PUBMED_8065454}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8065454 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8065454}}
==About this Structure==
==About this Structure==
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Initiator of blood coagulation in vertebrate]]
[[Category: Initiator of blood coagulation in vertebrate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:47:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:28:45 2008''

Revision as of 16:28, 30 June 2008

Image:1boy.png

Template:STRUCTURE 1boy

EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR

Template:ABSTRACT PUBMED 8065454

About this Structure

1BOY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the extracellular region of human tissue factor., Harlos K, Martin DM, O'Brien DP, Jones EY, Stuart DI, Polikarpov I, Miller A, Tuddenham EG, Boys CW, Nature. 1994 Aug 25;370(6491):662-6. PMID:8065454

Page seeded by OCA on Mon Jun 30 19:28:45 2008

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