1bqh

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[[Image:1bqh.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1bqh| PDB=1bqh | SCENE= }}
{{STRUCTURE_1bqh| PDB=1bqh | SCENE= }}
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'''MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8'''
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===MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8===
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==Overview==
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The crystal structure of the two immunoglobulin variable-like domains of the murine CD8alphaalpha homodimer complexed to the class I MHC H-2Kb molecule at 2.8 A resolution shows that CD8alphaalpha binds to the protruding MHC alpha3 domain loop in an antibody-like manner. Comparison of mouse CD8alphaalpha/H-2Kb and human CD8alphaalpha/HLA-A2 complexes reveals shared as well as species-specific recognition features. In both species, coreceptor function apparently involves the participation of CD8 dimer in a bidentate attachment to an MHC class I molecule in conjunction with a T cell receptor without discernable conformational alteration of the peptide or MHC antigen-presenting platform.
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(as it appears on PubMed at http://www.pubmed.gov), where 9806638 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9806638}}
==About this Structure==
==About this Structure==
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[[Category: Signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:49:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:32:13 2008''

Revision as of 16:32, 30 June 2008

Image:1bqh.png

Template:STRUCTURE 1bqh

MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8

Template:ABSTRACT PUBMED 9806638

About this Structure

1BQH is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb., Kern PS, Teng MK, Smolyar A, Liu JH, Liu J, Hussey RE, Spoerl R, Chang HC, Reinherz EL, Wang JH, Immunity. 1998 Oct;9(4):519-30. PMID:9806638

Page seeded by OCA on Mon Jun 30 19:32:13 2008

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