1bqu

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{{STRUCTURE_1bqu| PDB=1bqu | SCENE= }}
{{STRUCTURE_1bqu| PDB=1bqu | SCENE= }}
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'''CYTOKYNE-BINDING REGION OF GP130'''
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===CYTOKYNE-BINDING REGION OF GP130===
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==Overview==
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The structure of the cytokine-binding homology region of the cell surface receptor gp130 has been determined by X-ray crystallography at 2.0 A resolution. The beta sandwich structure of the two domains conforms to the topology of the cytokine receptor superfamily. This first structure of an uncomplexed receptor exhibits a similar L-shaped quaternary structure to that of ligand-bound family members and suggests a limited flexibility in relative domain orientation of some 3 degrees. The putative ligand-binding loops are relatively rigid, with a phenylalanine side chain similarly positioned to exposed aromatic residues implicated in ligand binding for other such receptors. The positioning and structure of the N-terminal portion of the polypeptide chain have implications for the structure and function of cytokine receptors, such as gp130, which contain an additional N-terminal immunoglobulin-like domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 9501088 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9501088}}
==About this Structure==
==About this Structure==
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[[Category: Gp130]]
[[Category: Gp130]]
[[Category: Interleukine 6 receptor beta subunit]]
[[Category: Interleukine 6 receptor beta subunit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:50:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:33:16 2008''

Revision as of 16:33, 30 June 2008

Image:1bqu.png

Template:STRUCTURE 1bqu

CYTOKYNE-BINDING REGION OF GP130

Template:ABSTRACT PUBMED 9501088

About this Structure

1BQU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a cytokine-binding region of gp130., Bravo J, Staunton D, Heath JK, Jones EY, EMBO J. 1998 Mar 16;17(6):1665-74. PMID:9501088

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