1br0

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[[Image:1br0.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1br0| PDB=1br0 | SCENE= }}
{{STRUCTURE_1br0| PDB=1br0 | SCENE= }}
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'''THREE DIMENSIONAL STRUCTURE OF THE N-TERMINAL DOMAIN OF SYNTAXIN 1A'''
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===THREE DIMENSIONAL STRUCTURE OF THE N-TERMINAL DOMAIN OF SYNTAXIN 1A===
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==Overview==
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Syntaxin 1A plays a central role in neurotransmitter release through multiple protein-protein interactions. We have used NMR spectroscopy to identify an autonomously folded N-terminal domain in syntaxin 1A and to elucidate its three-dimensional structure. This 120-residue N-terminal domain is conserved in plasma membrane syntaxins but not in other syntaxins, indicating a specific role in exocytosis. The domain contains three long alpha helices that form an up-and-down bundle with a left-handed twist. A striking residue conservation is observed throughout a long groove that is likely to provide a specific surface for protein-protein interactions. A highly acidic region binds to the C2A domain of synaptotagmin I in a Ca2+-dependent interaction that may serve as an electrostatic switch in neurotransmitter release.
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The line below this paragraph, {{ABSTRACT_PUBMED_9753330}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9753330 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9753330}}
==About this Structure==
==About this Structure==
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1BR0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR0 OCA].
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1BR0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR0 OCA].
==Reference==
==Reference==
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[[Category: Synaptic vesicle exocytosis]]
[[Category: Synaptic vesicle exocytosis]]
[[Category: Syntaxin]]
[[Category: Syntaxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:51:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:33:36 2008''

Revision as of 16:33, 30 June 2008

Image:1br0.png

Template:STRUCTURE 1br0

THREE DIMENSIONAL STRUCTURE OF THE N-TERMINAL DOMAIN OF SYNTAXIN 1A

Template:ABSTRACT PUBMED 9753330

About this Structure

1BR0 is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A., Fernandez I, Ubach J, Dulubova I, Zhang X, Sudhof TC, Rizo J, Cell. 1998 Sep 18;94(6):841-9. PMID:9753330

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