1br2

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[[Image:1br2.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1br2| PDB=1br2 | SCENE= }}
{{STRUCTURE_1br2| PDB=1br2 | SCENE= }}
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'''SMOOTH MUSCLE MYOSIN MOTOR DOMAIN COMPLEXED WITH MGADP.ALF4'''
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===SMOOTH MUSCLE MYOSIN MOTOR DOMAIN COMPLEXED WITH MGADP.ALF4===
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==Overview==
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The crystal structures of an expressed vertebrate smooth muscle myosin motor domain (MD) and a motor domain-essential light chain (ELC) complex (MDE), both with a transition state analog (MgADP x AIF4-) in the active site, have been determined to 2.9 A and 3.5 A resolution, respectively. The MDE structure with an ATP analog (MgADP x BeFx) was also determined to 3.6 A resolution. In all three structures, a domain of the C-terminal region, the "converter," is rotated approximately 70 degrees from that in nucleotide-free skeletal subfragment 1 (S1). We have found that the MDE-BeFx and MDE-AIF4- structures are almost identical, consistent with the fact that they both bind weakly to actin. A comparison of the lever arm positions in MDE-AIF4- and in nucleotide-free skeletal S1 shows that a potential displacement of approximately 10 nm can be achieved during the power stroke.
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(as it appears on PubMed at http://www.pubmed.gov), where 9741621 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9741621}}
==About this Structure==
==About this Structure==
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[[Category: Trybus, K M.]]
[[Category: Trybus, K M.]]
[[Category: Muscle protein]]
[[Category: Muscle protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:51:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:33:45 2008''

Revision as of 16:33, 30 June 2008

Image:1br2.png

Template:STRUCTURE 1br2

SMOOTH MUSCLE MYOSIN MOTOR DOMAIN COMPLEXED WITH MGADP.ALF4

Template:ABSTRACT PUBMED 9741621

About this Structure

1BR2 is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state., Dominguez R, Freyzon Y, Trybus KM, Cohen C, Cell. 1998 Sep 4;94(5):559-71. PMID:9741621

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