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1bte

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[[Image:1bte.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1bte| PDB=1bte | SCENE= }}
{{STRUCTURE_1bte| PDB=1bte | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE TYPE II ACTIVIN RECEPTOR'''
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===CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE TYPE II ACTIVIN RECEPTOR===
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==Overview==
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The transforming growth factor beta (TGFbeta) superfamily of cytokines elicit diverse biological responses by interacting with two distinct, but structurally related transmembrane receptor serine kinases (type I and type II). The binding of these dimeric ligands to the type II receptor is the first event in transmembrane signaling for this family. Here we report the 1.5 A resolution crystal structure of the extracellular ligand-binding domain of the type II activin receptor (ActRII-ECD), which reveals a fold similar to that of a class of toxins known as three-finger toxins. This fold is primarily dictated by disulfide bonds formed by eight conserved cysteines, with a characteristic spacing, and thus is likely to be shared by most of the type I and II receptors for the TGFbeta family. Sequence comparison with an evolutionarily distant activin binding-protein identifies several conserved residues, including two hydrophobic clusters that may form binding surfaces for activin and the type I receptor.
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The line below this paragraph, {{ABSTRACT_PUBMED_9886286}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9886286 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9886286}}
==About this Structure==
==About this Structure==
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[[Category: Serine kinase]]
[[Category: Serine kinase]]
[[Category: Three-finger toxin]]
[[Category: Three-finger toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:56:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:41:37 2008''

Revision as of 16:41, 30 June 2008

Image:1bte.png

Template:STRUCTURE 1bte

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE TYPE II ACTIVIN RECEPTOR

Template:ABSTRACT PUBMED 9886286

About this Structure

1BTE is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase., Greenwald J, Fischer WH, Vale WW, Choe S, Nat Struct Biol. 1999 Jan;6(1):18-22. PMID:9886286

Page seeded by OCA on Mon Jun 30 19:41:37 2008

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