1btw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1btw.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1btw.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1btw| PDB=1btw | SCENE= }}
{{STRUCTURE_1btw| PDB=1btw | SCENE= }}
-
'''EPISELECTION: NOVEL KI ~NANOMOLAR INHIBITORS OF SERINE PROTEASES SELECTED BY BINDING OR CHEMISTRY ON AN ENZYME SURFACE'''
+
===EPISELECTION: NOVEL KI ~NANOMOLAR INHIBITORS OF SERINE PROTEASES SELECTED BY BINDING OR CHEMISTRY ON AN ENZYME SURFACE===
-
==Overview==
+
<!--
-
A novel class of mechanism-based inhibitors of the serine proteases is developed using epitaxial selection. Tripeptide boronates esterified by an alcohol or alcohols at the boron retain the tight binding to trypsin-like enzymes associated with transition-state analogs and incorporate additional groups that can be utilized for selectivity between proteases. Formed by reaction of a series of alcohols with the inhibitor boronate oxygen(s), the most structurally compatible alcohol-derivatized inhibitors are either selected by binding to the enzyme (epitaxial selection) or assembled by epitaxial reaction on the enzyme surface. Mass spectrometry of the derivatized boronates and X-ray crystallography of the complexes identify the chemical structures and the three-dimensional interactions of inhibitors generated. This scheme also engineers novel, potent (Ki approximately 7 nM), and more specific inhibitors of individual serine proteases, by derivitizations of compounds obtained by epitaxial selection.
+
The line below this paragraph, {{ABSTRACT_PUBMED_7599119}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 7599119 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_7599119}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Stroud, R M.]]
[[Category: Stroud, R M.]]
[[Category: Tripeptideboronate 1,3-propanediol monoester-inhibited]]
[[Category: Tripeptideboronate 1,3-propanediol monoester-inhibited]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:57:06 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:42:57 2008''

Revision as of 16:42, 30 June 2008

Image:1btw.png

Template:STRUCTURE 1btw

EPISELECTION: NOVEL KI ~NANOMOLAR INHIBITORS OF SERINE PROTEASES SELECTED BY BINDING OR CHEMISTRY ON AN ENZYME SURFACE

Template:ABSTRACT PUBMED 7599119

About this Structure

1BTW is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface., Katz BA, Finer-Moore J, Mortezaei R, Rich DH, Stroud RM, Biochemistry. 1995 Jul 4;34(26):8264-80. PMID:7599119

Page seeded by OCA on Mon Jun 30 19:42:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1btw"
Personal tools