This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1btw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1btw.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1btw.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1btw| PDB=1btw | SCENE= }}
{{STRUCTURE_1btw| PDB=1btw | SCENE= }}
-
'''EPISELECTION: NOVEL KI ~NANOMOLAR INHIBITORS OF SERINE PROTEASES SELECTED BY BINDING OR CHEMISTRY ON AN ENZYME SURFACE'''
+
===EPISELECTION: NOVEL KI ~NANOMOLAR INHIBITORS OF SERINE PROTEASES SELECTED BY BINDING OR CHEMISTRY ON AN ENZYME SURFACE===
-
==Overview==
+
<!--
-
A novel class of mechanism-based inhibitors of the serine proteases is developed using epitaxial selection. Tripeptide boronates esterified by an alcohol or alcohols at the boron retain the tight binding to trypsin-like enzymes associated with transition-state analogs and incorporate additional groups that can be utilized for selectivity between proteases. Formed by reaction of a series of alcohols with the inhibitor boronate oxygen(s), the most structurally compatible alcohol-derivatized inhibitors are either selected by binding to the enzyme (epitaxial selection) or assembled by epitaxial reaction on the enzyme surface. Mass spectrometry of the derivatized boronates and X-ray crystallography of the complexes identify the chemical structures and the three-dimensional interactions of inhibitors generated. This scheme also engineers novel, potent (Ki approximately 7 nM), and more specific inhibitors of individual serine proteases, by derivitizations of compounds obtained by epitaxial selection.
+
The line below this paragraph, {{ABSTRACT_PUBMED_7599119}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 7599119 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_7599119}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Stroud, R M.]]
[[Category: Stroud, R M.]]
[[Category: Tripeptideboronate 1,3-propanediol monoester-inhibited]]
[[Category: Tripeptideboronate 1,3-propanediol monoester-inhibited]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:57:06 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:42:57 2008''

Revision as of 16:42, 30 June 2008

Image:1btw.png

Template:STRUCTURE 1btw

EPISELECTION: NOVEL KI ~NANOMOLAR INHIBITORS OF SERINE PROTEASES SELECTED BY BINDING OR CHEMISTRY ON AN ENZYME SURFACE

Template:ABSTRACT PUBMED 7599119

About this Structure

1BTW is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface., Katz BA, Finer-Moore J, Mortezaei R, Rich DH, Stroud RM, Biochemistry. 1995 Jul 4;34(26):8264-80. PMID:7599119

Page seeded by OCA on Mon Jun 30 19:42:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1btw"
Personal tools