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1buo

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[[Image:1buo.gif|left|200px]]
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{{STRUCTURE_1buo| PDB=1buo | SCENE= }}
{{STRUCTURE_1buo| PDB=1buo | SCENE= }}
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'''BTB DOMAIN FROM PLZF'''
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===BTB DOMAIN FROM PLZF===
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==Overview==
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The BTB domain (also known as the POZ domain) is an evolutionarily conserved protein-protein interaction motif found at the N terminus of 5-10% of C2H2-type zinc-finger transcription factors, as well as in some actin-associated proteins bearing the kelch motif. Many BTB proteins are transcriptional regulators that mediate gene expression through the control of chromatin conformation. In the human promyelocytic leukemia zinc finger (PLZF) protein, the BTB domain has transcriptional repression activity, directs the protein to a nuclear punctate pattern, and interacts with components of the histone deacetylase complex. The association of the PLZF BTB domain with the histone deacetylase complex provides a mechanism of linking the transcription factor with enzymatic activities that regulate chromatin conformation. The crystal structure of the BTB domain of PLZF was determined at 1.9 A resolution and reveals a tightly intertwined dimer with an extensive hydrophobic interface. Approximately one-quarter of the monomer surface area is involved in the dimer intermolecular contact. These features are typical of obligate homodimers, and we expect the full-length PLZF protein to exist as a branched transcription factor with two C-terminal DNA-binding regions. A surface-exposed groove lined with conserved amino acids is formed at the dimer interface, suggestive of a peptide-binding site. This groove may represent the site of interaction of the PLZF BTB domain with nuclear corepressors or other nuclear proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 9770450 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9770450}}
==About this Structure==
==About this Structure==
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[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
[[Category: Zinc-finger protein]]
[[Category: Zinc-finger protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:58:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:44:50 2008''

Revision as of 16:44, 30 June 2008

Image:1buo.png

Template:STRUCTURE 1buo

BTB DOMAIN FROM PLZF

Template:ABSTRACT PUBMED 9770450

About this Structure

1BUO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the BTB domain from PLZF., Ahmad KF, Engel CK, Prive GG, Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12123-8. PMID:9770450

Page seeded by OCA on Mon Jun 30 19:44:50 2008

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