1bxl

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[[Image:1bxl.gif|left|200px]]
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{{STRUCTURE_1bxl| PDB=1bxl | SCENE= }}
{{STRUCTURE_1bxl| PDB=1bxl | SCENE= }}
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'''STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE'''
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===STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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Heterodimerization between members of the Bcl-2 family of proteins is a key event in the regulation of programmed cell death. The molecular basis for heterodimer formation was investigated by determination of the solution structure of a complex between the survival protein Bcl-xL and the death-promoting region of the Bcl-2-related protein Bak. The structure and binding affinities of mutant Bak peptides indicate that the Bak peptide adopts an amphipathic alpha helix that interacts with Bcl-xL through hydrophobic and electrostatic interactions. Mutations in full-length Bak that disrupt either type of interaction inhibit the ability of Bak to heterodimerize with Bcl-xL.
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(as it appears on PubMed at http://www.pubmed.gov), where 9020082 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9020082}}
==About this Structure==
==About this Structure==
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1BXL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXL OCA].
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1BXL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXL OCA].
==Reference==
==Reference==
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[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
[[Category: Apoptosis]]
[[Category: Apoptosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:05:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:52:42 2008''

Revision as of 16:52, 30 June 2008

Image:1bxl.png

Template:STRUCTURE 1bxl

STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 9020082

About this Structure

1BXL is a Protein complex structure of sequences from Escherichia coli. Full experimental information is available from OCA.

Reference

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis., Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M, Yoon HS, Shuker SB, Chang BS, Minn AJ, Thompson CB, Fesik SW, Science. 1997 Feb 14;275(5302):983-6. PMID:9020082

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