1bxm

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{{STRUCTURE_1bxm| PDB=1bxm | SCENE= }}
{{STRUCTURE_1bxm| PDB=1bxm | SCENE= }}
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'''ENGINEERED BETA-CRYPTOGEIN COMPLEXED WITH ERGOSTEROL'''
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===ENGINEERED BETA-CRYPTOGEIN COMPLEXED WITH ERGOSTEROL===
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==Overview==
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Elicitins, produced by most of the phytopathogenic fungi of the genus Phytophthora, provoke in tobacco both remote leaf necrosis and the induction of a resistance against subsequent attack by various microorganisms. Despite the recent description of the three-dimensional crystal structure of cryptogein (CRY), the molecular basis of the interactions between Phytophthora and plants largely remains unknown. The X-ray crystal structure, refined at 2.1 A, of a ligand complexed, mutated CRY, K13H, is reported. Analysis of this structure reveals that CRY is able to encapsulate a ligand that induces only a minor conformational change in the protein structure. The ligand has been identified as an ergosterol by gas chromatographic analysis coupled with mass spectrometry analysis. This result is consistent with biochemical data that have shown that elicitins are a distinct class of Sterol Carrier Proteins (SCP). Data presented here provide the first structural description of the pertinent features of the elicitin sterol interaction and permit a reassessment of the importance of both the key residue 13 and the mobility of the omega loop for the accessibility of the sterol to the cavity. The biological implications thereof are discussed. This paper reports the first structure of a SCP/sterol complex.
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(as it appears on PubMed at http://www.pubmed.gov), where 10386869 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10386869}}
==About this Structure==
==About this Structure==
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[[Category: Plant pathogen]]
[[Category: Plant pathogen]]
[[Category: Sterol]]
[[Category: Sterol]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:05:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:52:48 2008''

Revision as of 16:52, 30 June 2008

Image:1bxm.png

Template:STRUCTURE 1bxm

ENGINEERED BETA-CRYPTOGEIN COMPLEXED WITH ERGOSTEROL

Template:ABSTRACT PUBMED 10386869

About this Structure

1BXM is a Single protein structure of sequence from Phytophthora cryptogea. Full crystallographic information is available from OCA.

Reference

The 2.1 A structure of an elicitin-ergosterol complex: a recent addition to the Sterol Carrier Protein family., Boissy G, O'Donohue M, Gaudemer O, Perez V, Pernollet JC, Brunie S, Protein Sci. 1999 Jun;8(6):1191-9. PMID:10386869

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