1by4

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[[Image:1by4.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1by4| PDB=1by4 | SCENE= }}
{{STRUCTURE_1by4| PDB=1by4 | SCENE= }}
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'''STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA'''
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===STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA===
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==Overview==
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The 9-cis retinoic acid receptor, RXR, binds DNA effectively as a homodimer or as a heterodimer with other nuclear receptors. The DNA-binding sites for these RXR complexes are direct repeats of a consensus sequence separated by one to five base-pairs of intervening space. Here, we report the 2.1 A crystal structure of the RXR-DNA-binding domain as a homodimer in complex with its idealized direct repeat DNA target. The structure shows how a gene-regulatory site can induce conformational changes in a transcription factor that promote homo-cooperative assembly. Specifically, an alpha-helix in the T-box is disrupted to allow efficient DNA-binding and subunit dimerization. RXR displays a relaxed mode of sequence recognition, interacting with only three base-pairs in each hexameric half-site. The structure illustrates how site selection is achieved in this large eukaryotic transcription factor family through discrete protein-protein interactions and the use of tandem DNA binding sites with characteristic spacings.
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The line below this paragraph, {{ABSTRACT_PUBMED_10669605}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10669605 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10669605}}
==About this Structure==
==About this Structure==
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[[Category: Protein-dna interation]]
[[Category: Protein-dna interation]]
[[Category: Rxr]]
[[Category: Rxr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:06:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:54:14 2008''

Revision as of 16:54, 30 June 2008

Image:1by4.png

Template:STRUCTURE 1by4

STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA

Template:ABSTRACT PUBMED 10669605

About this Structure

1BY4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of RXR-DNA interactions., Zhao Q, Chasse SA, Devarakonda S, Sierk ML, Ahvazi B, Rastinejad F, J Mol Biol. 2000 Feb 18;296(2):509-20. PMID:10669605

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