1byy

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[[Image:1byy.gif|left|200px]]
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{{Seed}}
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[[Image:1byy.png|left|200px]]
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{{STRUCTURE_1byy| PDB=1byy | SCENE= }}
{{STRUCTURE_1byy| PDB=1byy | SCENE= }}
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'''SODIUM CHANNEL IIA INACTIVATION GATE'''
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===SODIUM CHANNEL IIA INACTIVATION GATE===
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==Overview==
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The sodium channel initiates action potentials by opening in response to membrane depolarization. Fast channel inactivation, which is required for proper physiological function, is mediated by a cytoplasmic loop proposed to occlude the ion pore via a hinged lid mechanism with the triad IFM serving as a hydrophobic "latch". The NMR solution structure of the isolated inactivation gate reveals a stably folded core comprised of an alpha-helix capped by an N-terminal turn, supporting a model in which the tightly folded core containing the latch motif pivots on a more flexible hinge region to occlude the pore during inactivation. The structure, in combination with substituted cysteine mutagenesis experiments, indicates that the IFM triad and adjacent Thr are essential components of the latch and suggests differing roles for the residues of the IFMT motif in fast inactivation.
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The line below this paragraph, {{ABSTRACT_PUBMED_9893979}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9893979 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9893979}}
==About this Structure==
==About this Structure==
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1BYY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA].
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1BYY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA].
==Reference==
==Reference==
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[[Category: Scheuer, T.]]
[[Category: Scheuer, T.]]
[[Category: Sodium channel]]
[[Category: Sodium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:08:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:58:20 2008''

Revision as of 16:58, 30 June 2008

Image:1byy.png

Template:STRUCTURE 1byy

SODIUM CHANNEL IIA INACTIVATION GATE

Template:ABSTRACT PUBMED 9893979

About this Structure

1BYY is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Solution structure of the sodium channel inactivation gate., Rohl CA, Boeckman FA, Baker C, Scheuer T, Catterall WA, Klevit RE, Biochemistry. 1999 Jan 19;38(3):855-61. PMID:9893979

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