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1bzy

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{{STRUCTURE_1bzy| PDB=1bzy | SCENE= }}
{{STRUCTURE_1bzy| PDB=1bzy | SCENE= }}
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'''HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR'''
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===HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR===
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==Overview==
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The structure of human HGPRT bound to the transition-state analog immucillinGP and Mg2+-pyrophosphate has been determined to 2.0 A resolution. ImmucillinGP was designed as a stable analog with the stereoelectronic features of the transition state. Bound inhibitor at the catalytic site indicates that the oxocarbenium ion of the transition state is stabilized by neighboring-group participation from MgPPi and O5'. A short hydrogen bond forms between Asp 137 and the purine ring analog. Two Mg2+ ions sandwich the pyrophosphate and contact both hydroxyls of the ribosyl analog. The transition-state analog is shielded from bulk solvent by a catalytic loop that moves approximately 25 A to cover the active site and becomes an ordered antiparallel beta-sheet.
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(as it appears on PubMed at http://www.pubmed.gov), where 10360366 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10360366}}
==About this Structure==
==About this Structure==
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[[Category: Pyrophosphate]]
[[Category: Pyrophosphate]]
[[Category: Transition state]]
[[Category: Transition state]]
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Revision as of 17:01, 30 June 2008

Image:1bzy.png


PDB ID 1bzy

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1bzy, resolution 2.00Å ()
Ligands: , ,
Activity: Hypoxanthine phosphoribosyltransferase, with EC number 2.4.2.8
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR

Template:ABSTRACT PUBMED 10360366

About this Structure

1BZY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor., Shi W, Li CM, Tyler PC, Furneaux RH, Grubmeyer C, Schramm VL, Almo SC, Nat Struct Biol. 1999 Jun;6(6):588-93. PMID:10360366

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