1c11

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[[Image:1c11.gif|left|200px]]
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{{STRUCTURE_1c11| PDB=1c11 | SCENE= }}
{{STRUCTURE_1c11| PDB=1c11 | SCENE= }}
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'''INTERCALATED D(TCCCGTTTCCA) DIMER, NMR, 7 STRUCTURES'''
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===INTERCALATED D(TCCCGTTTCCA) DIMER, NMR, 7 STRUCTURES===
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==Overview==
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The solution structures of the oligodeoxynucleotides d(CCCGTTTCC) and d(TCCCGTTTCCA) have been determined by two-dimensional NMR spectroscopy. These oligomers are part of a DNA box in human centromeric alpha satellite targeted by the centromere protein B (CENP-B). Both CENP-B and its recognition box in alphoid DNA are conserved in mammals, suggesting an important biological role. At acidic pH, d(CCCGTTTCC), d(TCCCGTTTCCA) and the full d(TCCCGTTTCCAACGAAG) CENP-B box strand all fold and dimerize in solution forming a stable bimolecular structure containing two GTTT hairpin loops that interact through a novel T : G : G : T tetrad. The stem region of the dimer is a four-stranded intercalated motif in which the hairpin monomers are parallel and held together by C : C+ hydrogen-bonding and intercalation. The loops are at the same end of the dimer and lie across the narrow grooves of the tetraplex. They are remarkably structured and stabilized by base-base cross-stacking, sugar-base stacking, and parallel G:G and antiparallel G:T pairing. In the d(TCCCGTTTCCA)2 structure, the intercalated motif is continued at the other end of the dimer with unpaired but stacked adenine and thymine bases. The possible biological implications of these structures are discussed.Copyright 1997 Academic Press Limited
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(as it appears on PubMed at http://www.pubmed.gov), where 9367776 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9367776}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C11 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C11 OCA].
==Reference==
==Reference==
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[[Category: Hairpin]]
[[Category: Hairpin]]
[[Category: I-motif]]
[[Category: I-motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:03:41 2008''

Revision as of 17:03, 30 June 2008

Image:1c11.png

Template:STRUCTURE 1c11

INTERCALATED D(TCCCGTTTCCA) DIMER, NMR, 7 STRUCTURES

Template:ABSTRACT PUBMED 9367776

About this Structure

Full experimental information is available from OCA.

Reference

Centromeric pyrimidine strands fold into an intercalated motif by forming a double hairpin with a novel T:G:G:T tetrad: solution structure of the d(TCCCGTTTCCA) dimer., Gallego J, Chou SH, Reid BR, J Mol Biol. 1997 Nov 7;273(4):840-56. PMID:9367776

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