1c1y

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{{STRUCTURE_1c1y| PDB=1c1y | SCENE= }}
{{STRUCTURE_1c1y| PDB=1c1y | SCENE= }}
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'''CRYSTAL STRUCTURE OF RAP.GMPPNP IN COMPLEX WITH THE RAS-BINDING-DOMAIN OF C-RAF1 KINASE (RAFRBD).'''
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===CRYSTAL STRUCTURE OF RAP.GMPPNP IN COMPLEX WITH THE RAS-BINDING-DOMAIN OF C-RAF1 KINASE (RAFRBD).===
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==Overview==
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The X-ray crystal structure of the complex between the Ras-related protein Rap1A in the GTP-analogue (GppNHp) form and the Ras-binding domain (RBD) of the Ras effector molecule c-Raf1, a Ser/Thr-specific protein kinase, has been solved to a resolution of 2.2 A. It shows that RBD has the ubiquitin superfold and that the structure of Rap1A is very similar to that of Ras. The interaction between the two proteins is mediated by an apparent central antiparallel beta-sheet formed by strands B1-B2 from RBD and strands beta 2-beta 3 from Rap1A. Complex formation is mediated by main-chain and side-chain interactions of the so-called effector residues in the switch I region of Rap1A.
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The line below this paragraph, {{ABSTRACT_PUBMED_7791872}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7791872 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7791872}}
==About this Structure==
==About this Structure==
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[[Category: Gtp-binding protein]]
[[Category: Gtp-binding protein]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:14:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:05:55 2008''

Revision as of 17:05, 30 June 2008

Image:1c1y.png

Template:STRUCTURE 1c1y

CRYSTAL STRUCTURE OF RAP.GMPPNP IN COMPLEX WITH THE RAS-BINDING-DOMAIN OF C-RAF1 KINASE (RAFRBD).

Template:ABSTRACT PUBMED 7791872

About this Structure

1C1Y is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue., Nassar N, Horn G, Herrmann C, Scherer A, McCormick F, Wittinghofer A, Nature. 1995 Jun 15;375(6532):554-60. PMID:7791872

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