1c26

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1c26.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1c26.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1c26| PDB=1c26 | SCENE= }}
{{STRUCTURE_1c26| PDB=1c26 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF P53 TETRAMERIZATION DOMAIN'''
+
===CRYSTAL STRUCTURE OF P53 TETRAMERIZATION DOMAIN===
-
==Overview==
+
<!--
-
The p53 protein is a tetrameric transcription factor that plays a central role in the prevention of neoplastic transformation. Oligomerization appears to be essential for the tumor suppressing activity of p53 because oligomerization-deficient p53 mutants cannot suppress the growth of carcinoma cell lines. The crystal structure of the tetramerization domain of p53 (residues 325 to 356) was determined at 1.7 angstrom resolution and refined to a crystallographic R factor of 19.2 percent. The monomer, which consists of a beta strand and an alpha helix, associates with a second monomer across an antiparallel beta sheet and an antiparallel helix-helix interface to form a dimer. Two of these dimers associate across a second and distinct parallel helix-helix interface to form the tetramer.
+
The line below this paragraph, {{ABSTRACT_PUBMED_7878469}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 7878469 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_7878469}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Pavletich, N P.]]
[[Category: Pavletich, N P.]]
[[Category: Tetramer]]
[[Category: Tetramer]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:14:40 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:06:40 2008''

Revision as of 17:06, 30 June 2008

Image:1c26.png

Template:STRUCTURE 1c26

CRYSTAL STRUCTURE OF P53 TETRAMERIZATION DOMAIN

Template:ABSTRACT PUBMED 7878469

About this Structure

1C26 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms., Jeffrey PD, Gorina S, Pavletich NP, Science. 1995 Mar 10;267(5203):1498-502. PMID:7878469

Page seeded by OCA on Mon Jun 30 20:06:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1c26"
Personal tools