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1c32

From Proteopedia

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[[Image:1c32.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1c32| PDB=1c32 | SCENE= }}
{{STRUCTURE_1c32| PDB=1c32 | SCENE= }}
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'''SOLUTION STRUCTURE OF A QUADRUPLEX FORMING DNA AND ITS INTERMIDIATE'''
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===SOLUTION STRUCTURE OF A QUADRUPLEX FORMING DNA AND ITS INTERMIDIATE===
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==Overview==
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Potassium can stabilize the formation of chair- or edge-type quadruplex DNA structures and appears to be the only naturally occurring cation that can do so. As quadruplex DNAs may be important in the structure of telomere, centromere, triplet repeat and other DNAs, information about the details of the potassium-quadruplex DNA interactions are of interest. The structures of the 1:1 and the fully saturated, 2:1, potassium-DNA complexes of d(GGTTGGTGTGGTTGG) have been determined using the combination of experimental NMR results and restrained molecular dynamics simulations. The refined structures have been used to model the interactions at the potassium binding sites. Comparison of the 1:1 and 2:1 potassium:DNA structures indicates how potassium binding can determine the folding pattern of the DNA. In each binding site potassium interacts with the carbonyl oxygens of both the loop thymine residues and the guanine residues of the adjacent quartet.
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(as it appears on PubMed at http://www.pubmed.gov), where 10756199 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10756199}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C32 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C32 OCA].
==Reference==
==Reference==
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[[Category: Quadruplex]]
[[Category: Quadruplex]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:16:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:08:31 2008''

Revision as of 17:08, 30 June 2008

Image:1c32.png

Template:STRUCTURE 1c32

SOLUTION STRUCTURE OF A QUADRUPLEX FORMING DNA AND ITS INTERMIDIATE

Template:ABSTRACT PUBMED 10756199

About this Structure

Full experimental information is available from OCA.

Reference

Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA., Marathias VM, Bolton PH, Nucleic Acids Res. 2000 May 1;28(9):1969-77. PMID:10756199

Page seeded by OCA on Mon Jun 30 20:08:31 2008

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