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1c4p

From Proteopedia

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[[Image:1c4p.gif|left|200px]]
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{{STRUCTURE_1c4p| PDB=1c4p | SCENE= }}
{{STRUCTURE_1c4p| PDB=1c4p | SCENE= }}
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'''BETA DOMAIN OF STREPTOKINASE'''
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===BETA DOMAIN OF STREPTOKINASE===
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==Overview==
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Streptokinase, a 47 kDa secreted protein of hemolytic strains of streptococci, is a human plasminogen activator and contains three structural domains linked by flexible loops. We describe here the crystal structure of the isolated streptokinase middle (SKbeta) domain determined at 2.4 A resolution. Among the functionally important structural features is a putative binding site for a kringle domain of plasminogen located at the tip of a fully exposed hairpin loop. The distribution of genetically conserved residues of SKbeta is strongly correlated with their functions. The extensive interface of the SKbeta dimer suggests that such dimers may also exist in solution for free SKbeta.
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The line below this paragraph, {{ABSTRACT_PUBMED_10508922}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10508922 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10508922}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, X C.]]
[[Category: Zhang, X C.]]
[[Category: Plasminogen activator]]
[[Category: Plasminogen activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:19:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:12:12 2008''

Revision as of 17:12, 30 June 2008

Image:1c4p.png

Template:STRUCTURE 1c4p

BETA DOMAIN OF STREPTOKINASE

Template:ABSTRACT PUBMED 10508922

About this Structure

1C4P is a Single protein structure of sequence from Streptococcus dysgalactiae subsp. equisimilis. Full crystallographic information is available from OCA.

Reference

Crystal structure of streptokinase beta-domain., Wang X, Tang J, Hunter B, Zhang XC, FEBS Lett. 1999 Oct 1;459(1):85-9. PMID:10508922

Page seeded by OCA on Mon Jun 30 20:12:12 2008

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