1c5a

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{{STRUCTURE_1c5a| PDB=1c5a | SCENE= }}
{{STRUCTURE_1c5a| PDB=1c5a | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF PORCINE C5ADES*ARG FROM 1H NUCLEAR MAGNETIC RESONANCE DATA'''
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===THREE-DIMENSIONAL STRUCTURE OF PORCINE C5ADES*ARG FROM 1H NUCLEAR MAGNETIC RESONANCE DATA===
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==Overview==
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Two-dimensional nuclear magnetic resonance spectra of porcine C5adesArg (73 residues) have been used to construct a list of 34 hydrogen bonds, 27 dihedral angle constraints, and 151 distance constraints, derived from nuclear Overhauser effect data. These constraints were used in restrained molecular dynamics calculations on residues 1-65 of C5a, starting from a folded structure modeled on the crystal structure of a homologous protein, C3a. Forty-one structures have been calculated, which fall into three similar families with few violations of the imposed constraints. Structures in the most populated family have a root-mean-square deviation from the average structure of 1.02 A for the C alpha atoms, with good definition of the internal residues. There is good agreement between the calculated structures and other nuclear magnetic resonance data. The structure is very similar to that recently reported for human C5a [Zuiderweg et al. (1989) Biochemistry 28, 172-185]. Some biological implications of these structures are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 2337573 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2337573}}
==About this Structure==
==About this Structure==
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1C5A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa_domestica Sus scrofa domestica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5A OCA].
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1C5A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa_domestica Sus scrofa domestica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5A OCA].
==Reference==
==Reference==
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[[Category: Williamson, M P.]]
[[Category: Williamson, M P.]]
[[Category: Complement factor]]
[[Category: Complement factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:20:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:13:49 2008''

Revision as of 17:13, 30 June 2008

Image:1c5a.png

Template:STRUCTURE 1c5a

THREE-DIMENSIONAL STRUCTURE OF PORCINE C5ADES*ARG FROM 1H NUCLEAR MAGNETIC RESONANCE DATA

Template:ABSTRACT PUBMED 2337573

About this Structure

1C5A is a Single protein structure of sequence from Sus scrofa domestica. Full experimental information is available from OCA.

Reference

Three-dimensional structure of porcine C5adesArg from 1H nuclear magnetic resonance data., Williamson MP, Madison VS, Biochemistry. 1990 Mar 27;29(12):2895-905. PMID:2337573

Page seeded by OCA on Mon Jun 30 20:13:49 2008

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