1c5c

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{{STRUCTURE_1c5c| PDB=1c5c | SCENE= }}
{{STRUCTURE_1c5c| PDB=1c5c | SCENE= }}
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'''DECARBOXYLASE CATALYTIC ANTIBODY 21D8-HAPTEN COMPLEX'''
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===DECARBOXYLASE CATALYTIC ANTIBODY 21D8-HAPTEN COMPLEX===
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==Overview==
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Antibody 21D8 catalyzes the solvent-sensitive decarboxylation of 3-carboxybenzisoxazoles. The crystal structure of chimeric Fab 21D8 with and without hapten at 1.61 A and 2.10 A, respectively, together with computational analysis, shows how a melange of polar and non-polar sites are exploited to achieve both substrate binding and acceleration of a reaction normally facilitated by purely aprotic dipolar media. The striking similarity of the decarboxylase and a series of unrelated esterase antibodies also highlights the chemical versatility of structurally conserved anion binding sites and the relatively subtle changes involved in fine-tuning the immunoglobulin pocket for recognition of different ligands and catalysis of different reactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 11183784 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11183784}}
==About this Structure==
==About this Structure==
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[[Category: Hapten complex]]
[[Category: Hapten complex]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:20:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:13:50 2008''

Revision as of 17:13, 30 June 2008

Image:1c5c.png

Template:STRUCTURE 1c5c

DECARBOXYLASE CATALYTIC ANTIBODY 21D8-HAPTEN COMPLEX

Template:ABSTRACT PUBMED 11183784

About this Structure

Full crystallographic information is available from OCA.

Reference

Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8., Hotta K, Lange H, Tantillo DJ, Houk KN, Hilvert D, Wilson IA, J Mol Biol. 2000 Oct 6;302(5):1213-25. PMID:11183784

Page seeded by OCA on Mon Jun 30 20:13:50 2008

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