2bfy
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(New page: 200px<br /> <applet load="2bfy" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bfy, resolution 1.80Å" /> '''COMPLEX OF AURORA-B...)
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Revision as of 17:38, 29 October 2007
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COMPLEX OF AURORA-B WITH INCENP AND HESPERIDIN.
Overview
Aurora family serine/threonine kinases control mitotic progression, and, their deregulation is implicated in tumorigenesis. Aurora A and Aurora B, the best-characterized members of mammalian Aurora kinases, are, approximately 60% identical but bind to unrelated activating subunits. The, structure of the complex of Aurora A with the TPX2 activator has been, reported previously. Here, we report the crystal structure of Aurora B in, complex with the IN-box segment of the inner centromere protein (INCENP), activator and with the small molecule inhibitor Hesperadin. The Aurora, B:INCENP complex is remarkably different from the Aurora A:TPX2 complex., INCENP forms a crown around the small lobe of Aurora B and induces the, active conformation of the T loop allosterically. The structure ... [(full description)]
About this Structure
2BFY is a [Protein complex] structure of sequences from [Xenopus laevis] with H1N as [ligand]. Full crystallographic information is available from [OCA].
Reference
Mechanism of Aurora B activation by INCENP and inhibition by hesperadin., Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A, Mol Cell. 2005 Apr 29;18(3):379-91. PMID:15866179
Page seeded by OCA on Mon Oct 29 19:43:08 2007
