1c89

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{{STRUCTURE_1c89| PDB=1c89 | SCENE= }}
{{STRUCTURE_1c89| PDB=1c89 | SCENE= }}
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'''NMR STRUCTURE OF INTRAMOLECULAR DIMER ANTIFREEZE PROTEIN RD3, 40 SA STRUCTURES'''
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===NMR STRUCTURE OF INTRAMOLECULAR DIMER ANTIFREEZE PROTEIN RD3, 40 SA STRUCTURES===
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==Overview==
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The structure of a new antifreeze protein (AFP) variant, RD3, from antarctic eel pout (Rhigophila dearborni) with enhanced activity has been determined for the first time by nuclear magnetic resonance spectroscopy. RD3 comprises a unique translational topology of two homologous type III AFP globular domains, each containing one flat, ice binding plane. The ice binding plane of the N domain is located approximately 3.5 A "behind" that of the C domain. The two ice binding planes are located laterally with an angle of 32 +/- 12 degrees between the planes. These results suggest that the C domain plane of RD3 binds first to the ice [1010] prism plane in the &lt;0001&gt; direction, which induces successive ice binding of the N domain in the &lt;0101&gt; direction. This manner of ice binding caused by the unique structural topology of RD3 is thought to be crucial for the significant enhancement of antifreeze activity, especially at low AFP concentrations.
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{{ABSTRACT_PUBMED_11010977}}
==About this Structure==
==About this Structure==
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1C89 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pachycara_brachycephalum Pachycara brachycephalum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C89 OCA].
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1C89 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pachycara_brachycephalum Pachycara brachycephalum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C89 OCA].
==Reference==
==Reference==
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[[Category: Ice binding protein]]
[[Category: Ice binding protein]]
[[Category: Thermal hysteresis protein]]
[[Category: Thermal hysteresis protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:27:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:21:14 2008''

Revision as of 17:21, 30 June 2008

Image:1c89.png

Template:STRUCTURE 1c89

NMR STRUCTURE OF INTRAMOLECULAR DIMER ANTIFREEZE PROTEIN RD3, 40 SA STRUCTURES

Template:ABSTRACT PUBMED 11010977

About this Structure

1C89 is a Single protein structure of sequence from Pachycara brachycephalum. Full experimental information is available from OCA.

Reference

NMR analysis of type III antifreeze protein intramolecular dimer. Structural basis for enhanced activity., Miura K, Ohgiya S, Hoshino T, Nemoto N, Suetake T, Miura A, Spyracopoulos L, Kondo H, Tsuda S, J Biol Chem. 2001 Jan 12;276(2):1304-10. PMID:11010977

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