1c9i

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{{STRUCTURE_1c9i| PDB=1c9i | SCENE= }}
{{STRUCTURE_1c9i| PDB=1c9i | SCENE= }}
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'''PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN'''
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===PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN===
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==Overview==
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The "WD40" domain is a widespread recognition module for linking partner proteins in intracellular networks of signaling and sorting. The clathrin amino-terminal domain, which directs incorporation of cargo into coated pits, is a beta-propeller closely related in structure to WD40 modules. The crystallographically determined structures of complexes of the clathrin-terminal domain with peptides derived from two different cargo adaptors, beta-arrestin 2 and the beta-subunit of the AP-3 complex, reveal strikingly similar peptide-in-groove interactions. The two peptides in our structures contain related, five-residue motifs, which form the core of their contact with clathrin. A number of other proteins involved in endocytosis have similar "clathrin-box" motifs, and it therefore is likely that they all bind the terminal domain in the same way. We propose that a peptide-in-groove interaction is an important general mode by which beta-propellers recognize specific target proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 10655490 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10655490}}
==About this Structure==
==About this Structure==
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[[Category: Beta-propeller]]
[[Category: Beta-propeller]]
[[Category: Helical hairpin]]
[[Category: Helical hairpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:29:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:24:25 2008''

Revision as of 17:24, 30 June 2008

Image:1c9i.png

Template:STRUCTURE 1c9i

PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN

Template:ABSTRACT PUBMED 10655490

About this Structure

1C9I is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin., ter Haar E, Harrison SC, Kirchhausen T, Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1096-100. PMID:10655490

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