1c9q

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{{STRUCTURE_1c9q| PDB=1c9q | SCENE= }}
{{STRUCTURE_1c9q| PDB=1c9q | SCENE= }}
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'''AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-2 DOMAIN OF XIAP'''
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===AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-2 DOMAIN OF XIAP===
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==Overview==
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The inhibitor-of-apoptosis (IAP) family of proteins, originally identified in baculoviruses, regulate programmed cell death in a variety of organisms. IAPs inhibit specific enzymes (caspases) in the death cascade and contain one to three modules of a common 70-amino-acid motif called the BIR domain. Here we describe the nuclear magnetic resonance structure of a region encompassing the second BIR domain (BIR2) of a human IAP family member, XIAP (also called hILP or MIHA). The structure of the BIR domain consists of a three-stranded antiparallel beta-sheet and four alpha-helices and resembles a classical zinc finger. Unexpectedly, conserved amino acids within the linker region between the BIR1 and BIR2 domains were found to be critical for inhibiting caspase-3. The absence or presence of these residues may explain the differences in caspase inhibition observed for different truncated and full-length IAPs. Our data further indicate that these residues may bind to the active site and that the BIR domain may interact with an adjacent site on the enzyme.
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{{ABSTRACT_PUBMED_10548111}}
==About this Structure==
==About this Structure==
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1C9Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C9Q OCA].
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1C9Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C9Q OCA].
==Reference==
==Reference==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:24:58 2008''

Revision as of 17:25, 30 June 2008

Image:1c9q.png

Template:STRUCTURE 1c9q

AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-2 DOMAIN OF XIAP

Template:ABSTRACT PUBMED 10548111

About this Structure

1C9Q is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP., Sun C, Cai M, Gunasekera AH, Meadows RP, Wang H, Chen J, Zhang H, Wu W, Xu N, Ng SC, Fesik SW, Nature. 1999 Oct 21;401(6755):818-22. PMID:10548111

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