1cbx

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[[Image:1cbx.gif|left|200px]]
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{{STRUCTURE_1cbx| PDB=1cbx | SCENE= }}
{{STRUCTURE_1cbx| PDB=1cbx | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CARBOXYPEPTIDASE A AND THE BIPRODUCT ANALOG INHIBITOR L-BENZYLSUCCINATE AT 2.0 ANGSTROMS RESOLUTION'''
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===CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CARBOXYPEPTIDASE A AND THE BIPRODUCT ANALOG INHIBITOR L-BENZYLSUCCINATE AT 2.0 ANGSTROMS RESOLUTION===
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==Overview==
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The X-ray crystal structure of the carboxypeptidase A-L-benzylsuccinate complex has been refined at 2.0 A resolution to a final R-factor of 0.166. One molecule of the inhibitor binds to the enzyme active site. The terminal carboxylate forms a salt link with the guanidinium group of Arg145 and hydrogen bonds with Tyr248 and Asn144. The second carboxylate group binds to the zinc ion in an asymmetric bidentate fashion replacing the water molecule of the native structure. The zinc ion moves 0.5 A from its position in the native structure to accommodate the inhibitor binding. The overall stereochemistry around the zinc can be considered a distorted tetrahedron, although six atoms of the co-ordinated groups lie within 3.0 A from the zinc ion. The key for the strong inhibitory properties of L-benzylsuccinate can be found in its ability both to co-ordinate the zinc and to form a short carboxyl-carboxylate-type hydrogen bond (2.5 A) with Glu270.
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(as it appears on PubMed at http://www.pubmed.gov), where 1738164 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1738164}}
==About this Structure==
==About this Structure==
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[[Category: Mangani, S.]]
[[Category: Mangani, S.]]
[[Category: Orioli, P.]]
[[Category: Orioli, P.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:33:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:31:47 2008''

Revision as of 17:31, 30 June 2008

Image:1cbx.png

Template:STRUCTURE 1cbx

CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CARBOXYPEPTIDASE A AND THE BIPRODUCT ANALOG INHIBITOR L-BENZYLSUCCINATE AT 2.0 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 1738164

About this Structure

1CBX is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the complex between carboxypeptidase A and the biproduct analog inhibitor L-benzylsuccinate at 2.0 A resolution., Mangani S, Carloni P, Orioli P, J Mol Biol. 1992 Jan 20;223(2):573-8. PMID:1738164

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