1ce4

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[[Image:1ce4.gif|left|200px]]
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{{STRUCTURE_1ce4| PDB=1ce4 | SCENE= }}
{{STRUCTURE_1ce4| PDB=1ce4 | SCENE= }}
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'''CONFORMATIONAL MODEL FOR THE CONSENSUS V3 LOOP OF THE ENVELOPE PROTEIN GP120 OF HIV-1'''
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===CONFORMATIONAL MODEL FOR THE CONSENSUS V3 LOOP OF THE ENVELOPE PROTEIN GP120 OF HIV-1===
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==Overview==
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The disulfide bridge closed cyclic peptide corresponding to the whole Consensus V3 loop of the envelope protein gp120 of HIV-1 was examined by proton 2D-NMR spectroscopy in water and in a 20% trifluoroethanol/water solution. In water, NOE data support a beta-turn conformation for the central conservative GPGR region and point towards partial formation of a helix in the C-terminal part. Upon addition of trifluoroethanol, a C-terminal helix is formed. This is evidenced by NOE data, alpha-proton chemical shift changes and changes in the JN alpha vicinal coupling constants. The C-terminal helix is amphipathic and also occurs in other examined strains. It could therefore be an important feature for the functioning of the V3 loop.
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The line below this paragraph, {{ABSTRACT_PUBMED_7589496}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7589496 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7589496}}
==About this Structure==
==About this Structure==
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1CE4 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CE4 OCA].
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1CE4 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CE4 OCA].
==Reference==
==Reference==
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[[Category: Amphipathic helix]]
[[Category: Amphipathic helix]]
[[Category: Hiv infection]]
[[Category: Hiv infection]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:37:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:37:12 2008''

Revision as of 17:37, 30 June 2008

Image:1ce4.png

Template:STRUCTURE 1ce4

CONFORMATIONAL MODEL FOR THE CONSENSUS V3 LOOP OF THE ENVELOPE PROTEIN GP120 OF HIV-1

Template:ABSTRACT PUBMED 7589496

About this Structure

1CE4 is a Single protein structure. Full experimental information is available from OCA.

Reference

The complete Consensus V3 loop peptide of the envelope protein gp120 of HIV-1 shows pronounced helical character in solution., Vranken WF, Budesinsky M, Fant F, Boulez K, Borremans FA, FEBS Lett. 1995 Oct 23;374(1):117-21. PMID:7589496

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