1cf4

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{{STRUCTURE_1cf4| PDB=1cf4 | SCENE= }}
{{STRUCTURE_1cf4| PDB=1cf4 | SCENE= }}
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'''CDC42/ACK GTPASE-BINDING DOMAIN COMPLEX'''
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===CDC42/ACK GTPASE-BINDING DOMAIN COMPLEX===
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==Overview==
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The proteins Cdc42 and Rac are members of the Rho family of small GTPases (G proteins), which control signal-transduction pathways that lead to rearrangements of the cell cytoskeleton, cell differentiation and cell proliferation. They do so by binding to downstream effector proteins. Some of these, known as CRIB (for Cdc42/Rac interactive-binding) proteins, bind to both Cdc42 and Rac, such as the PAK1-3 serine/threonine kinases, whereas others are specific for Cdc42, such as the ACK tyrosine kinases and the Wiscott-Aldrich-syndrome proteins (WASPs). The effector loop of Cdc42 and Rac (comprising residues 30-40, also called switch I), is one of two regions which change conformation on exchange of GDP for GTP. This region is almost identical in Cdc42 and Racs, indicating that it does not determine the specificity of these G proteins. Here we report the solution structure of the complex of Cdc42 with the GTPase-binding domain ofACK. Both proteins undergo significant conformational changes on binding, to form a new type of G-protein/effector complex. The interaction extends the beta-sheet in Cdc42 by binding an extended strand from ACK, as seen in Ras/effector interactions, but it also involves other regions of the G protein that are important for determining the specificity of effector binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 10360579 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10360579}}
==About this Structure==
==About this Structure==
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1CF4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CF4 OCA].
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1CF4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CF4 OCA].
==Reference==
==Reference==
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[[Category: G protein]]
[[Category: G protein]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:39:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:39:41 2008''

Revision as of 17:39, 30 June 2008

Image:1cf4.png

Template:STRUCTURE 1cf4

CDC42/ACK GTPASE-BINDING DOMAIN COMPLEX

Template:ABSTRACT PUBMED 10360579

About this Structure

1CF4 is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK., Mott HR, Owen D, Nietlispach D, Lowe PN, Manser E, Lim L, Laue ED, Nature. 1999 May 27;399(6734):384-8. PMID:10360579

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