1cfb

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{{STRUCTURE_1cfb| PDB=1cfb | SCENE= }}
{{STRUCTURE_1cfb| PDB=1cfb | SCENE= }}
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'''CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS'''
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===CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS===
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==Overview==
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We report the crystal structure of two adjacent fibronectin type III repeats from the Drosophila neural cell adhesion molecule neuroglian. Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type III domains from the extracellular matrix proteins tenascin and fibronectin. beta bulges and left-handed polyproline II helices disrupt the regular beta sheet structure of both neuroglian domains. The hydrophobic interdomain interface includes a metal-binding site, presumably involved in stabilizing the relative orientation between domains and predicted by sequence comparision to be present in the vertebrate homolog molecule L1. The neuroglian domains are related by a near perfect 2-fold screw axis along the longest molecular dimension. Using this relationship, a model for arrays of tandem fibronectin type III repeats in neuroglian and other molecules is proposed.
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(as it appears on PubMed at http://www.pubmed.gov), where 7512815 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7512815}}
==About this Structure==
==About this Structure==
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[[Category: Wang, Y E.]]
[[Category: Wang, Y E.]]
[[Category: Neural adhesion molecule]]
[[Category: Neural adhesion molecule]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:40:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:40:28 2008''

Revision as of 17:40, 30 June 2008

Image:1cfb.png

Template:STRUCTURE 1cfb

CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS

Template:ABSTRACT PUBMED 7512815

About this Structure

1CFB is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Crystal structure of tandem type III fibronectin domains from Drosophila neuroglian at 2.0 A., Huber AH, Wang YM, Bieber AJ, Bjorkman PJ, Neuron. 1994 Apr;12(4):717-31. PMID:7512815

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