1cfs

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{{Seed}}
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{{STRUCTURE_1cfs| PDB=1cfs | SCENE= }}
{{STRUCTURE_1cfs| PDB=1cfs | SCENE= }}
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'''ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-UNRELATED PEPTIDE'''
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===ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-UNRELATED PEPTIDE===
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==Overview==
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The X-ray crystal structures of an anti-p24 (HIV-1) monoclonal antibody Fab fragment alone and in complexes with the epitope peptide GATPQDLNTnL (n = norleucine), an epitope-homologous peptide GATPEDLNQKLAGN, as well as two unrelated peptides GLYEWGGARITNTD and efslkGpllqwrsG (D-peptide), are presented to a maximum resolution of 2.6 A. The latter three peptides were identified from screening synthetic combinatorial peptide libraries. Although all peptides bind to the same antigen combining site, the nonhomologous peptides adopt different binding conformations and also form their critical contacts with different antibody residues. Only small readjustments are observed within the framework of the Fab fragment upon binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 9413990 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9413990}}
==About this Structure==
==About this Structure==
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[[Category: Peptide]]
[[Category: Peptide]]
[[Category: Polyspecificity]]
[[Category: Polyspecificity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:41:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:41:40 2008''

Revision as of 17:41, 30 June 2008

Image:1cfs.png

Template:STRUCTURE 1cfs

ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-UNRELATED PEPTIDE

Template:ABSTRACT PUBMED 9413990

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of anti-p24 (HIV-1) monoclonal antibody cross-reactivity and polyspecificity., Keitel T, Kramer A, Wessner H, Scholz C, Schneider-Mergener J, Hohne W, Cell. 1997 Dec 12;91(6):811-20. PMID:9413990

Page seeded by OCA on Mon Jun 30 20:41:40 2008

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