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| | {{STRUCTURE_1cgd| PDB=1cgd | SCENE= }} | | {{STRUCTURE_1cgd| PDB=1cgd | SCENE= }} |
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| - | '''HYDRATION STRUCTURE OF A COLLAGEN PEPTIDE'''
| + | ===HYDRATION STRUCTURE OF A COLLAGEN PEPTIDE=== |
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| - | ==Overview==
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| - | BACKGROUND: The collagen triple helix is a unique protein motif defined by the supercoiling of three polypeptide chains in a polyproline II conformation. It is a major domain of all collagen proteins and is also reported to exist in proteins with host defense function and in several membrane proteins. The triple-helical domain has distinctive properties. Collagen requires a high proportion of the post-translationally modified imino acid 4-hydroxyproline and water to stabilize its conformation and assembly. The crystal structure of a collagen-like peptide determined to 1.85 Angstrum showed that these two features may be related. RESULTS: A detailed analysis of the hydration structure of the collagen-like peptide is presented. The water molecules around the carbonyl and hydroxyprolyl groups show distinctive geometries. There are repetitive patterns of water bridges that link oxygen atoms within a single peptide chain, between different chains and between different triple helices. Overall, the water molecules are organized in a semi-clathrate-like structure that surrounds and interconnects triple helices in the crystal lattice. Hydroxyprolyl groups play a crucial role in the assembly. CONCLUSIONS: The roles of hydroxyproline and hydration are strongly interrelated in the structure of the collagen triple helix. The specific, repetitive water bridges observed in this structure buttress the triple-helical conformation. The extensively ordered hydration structure offers a good model for the interpretation of the experimental results on collagen stability and assembly.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_8535783}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 8535783 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_8535783}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Extracellular matrix]] | | [[Category: Extracellular matrix]] |
| | [[Category: Hydroxyproline]] | | [[Category: Hydroxyproline]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:42:28 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:42:46 2008'' |
Revision as of 17:42, 30 June 2008
Template:STRUCTURE 1cgd
HYDRATION STRUCTURE OF A COLLAGEN PEPTIDE
Template:ABSTRACT PUBMED 8535783
About this Structure
Full crystallographic information is available from OCA.
Reference
Hydration structure of a collagen peptide., Bella J, Brodsky B, Berman HM, Structure. 1995 Sep 15;3(9):893-906. PMID:8535783
Page seeded by OCA on Mon Jun 30 20:42:46 2008
