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1cgd

From Proteopedia

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[[Image:1cgd.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1cgd| PDB=1cgd | SCENE= }}
{{STRUCTURE_1cgd| PDB=1cgd | SCENE= }}
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'''HYDRATION STRUCTURE OF A COLLAGEN PEPTIDE'''
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===HYDRATION STRUCTURE OF A COLLAGEN PEPTIDE===
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==Overview==
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BACKGROUND: The collagen triple helix is a unique protein motif defined by the supercoiling of three polypeptide chains in a polyproline II conformation. It is a major domain of all collagen proteins and is also reported to exist in proteins with host defense function and in several membrane proteins. The triple-helical domain has distinctive properties. Collagen requires a high proportion of the post-translationally modified imino acid 4-hydroxyproline and water to stabilize its conformation and assembly. The crystal structure of a collagen-like peptide determined to 1.85 Angstrum showed that these two features may be related. RESULTS: A detailed analysis of the hydration structure of the collagen-like peptide is presented. The water molecules around the carbonyl and hydroxyprolyl groups show distinctive geometries. There are repetitive patterns of water bridges that link oxygen atoms within a single peptide chain, between different chains and between different triple helices. Overall, the water molecules are organized in a semi-clathrate-like structure that surrounds and interconnects triple helices in the crystal lattice. Hydroxyprolyl groups play a crucial role in the assembly. CONCLUSIONS: The roles of hydroxyproline and hydration are strongly interrelated in the structure of the collagen triple helix. The specific, repetitive water bridges observed in this structure buttress the triple-helical conformation. The extensively ordered hydration structure offers a good model for the interpretation of the experimental results on collagen stability and assembly.
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The line below this paragraph, {{ABSTRACT_PUBMED_8535783}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8535783 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8535783}}
==About this Structure==
==About this Structure==
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[[Category: Extracellular matrix]]
[[Category: Extracellular matrix]]
[[Category: Hydroxyproline]]
[[Category: Hydroxyproline]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:42:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:42:46 2008''

Revision as of 17:42, 30 June 2008

Image:1cgd.png

Template:STRUCTURE 1cgd

HYDRATION STRUCTURE OF A COLLAGEN PEPTIDE

Template:ABSTRACT PUBMED 8535783

About this Structure

Full crystallographic information is available from OCA.

Reference

Hydration structure of a collagen peptide., Bella J, Brodsky B, Berman HM, Structure. 1995 Sep 15;3(9):893-906. PMID:8535783

Page seeded by OCA on Mon Jun 30 20:42:46 2008

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