1cgl

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[[Image:1cgl.gif|left|200px]]
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{{STRUCTURE_1cgl| PDB=1cgl | SCENE= }}
{{STRUCTURE_1cgl| PDB=1cgl | SCENE= }}
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'''STRUCTURE OF THE CATALYTIC DOMAIN OF FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR'''
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===STRUCTURE OF THE CATALYTIC DOMAIN OF FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR===
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==Overview==
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Collagenase is a zinc-dependent endoproteinase and is a member of the matrix metalloproteinase (MMP) family of enzymes. The MMPs participate in connective tissue remodeling events and aberrant regulation has been associated with several pathologies. The 2.4 angstrom resolution structure of the inhibited enzyme revealed that, in addition to the catalytic zinc, there is a second zinc ion and a calcium ion which play a major role in stabilizing the tertiary structure of collagenase. Despite scant sequence homology, collagenase shares structural homology with two other endoproteinases, bacterial thermolysin and crayfish astacin. The detailed description of protein-inhibitor interactions present in the structure will aid in the design of compounds that selectively inhibit individual members of the MMP family. Such inhibitors will be useful in examining the function of MMPs in pathological processes.
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(as it appears on PubMed at http://www.pubmed.gov), where 8278810 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8278810}}
==About this Structure==
==About this Structure==
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[[Category: Weigl, D.]]
[[Category: Weigl, D.]]
[[Category: Metalloprotease]]
[[Category: Metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:42:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:43:20 2008''

Revision as of 17:43, 30 June 2008

Image:1cgl.png

Template:STRUCTURE 1cgl

STRUCTURE OF THE CATALYTIC DOMAIN OF FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR

Template:ABSTRACT PUBMED 8278810

About this Structure

1CGL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor., Lovejoy B, Cleasby A, Hassell AM, Longley K, Luther MA, Weigl D, McGeehan G, McElroy AB, Drewry D, Lambert MH, et al., Science. 1994 Jan 21;263(5145):375-7. PMID:8278810

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