1ch4

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{{STRUCTURE_1ch4| PDB=1ch4 | SCENE= }}
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'''MODULE-SUBSTITUTED CHIMERA HEMOGLOBIN BETA-ALPHA (F133V)'''
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===MODULE-SUBSTITUTED CHIMERA HEMOGLOBIN BETA-ALPHA (F133V)===
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==Overview==
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The crystal structure of the homotetramer of a chimera beta alpha-subunit of human hemoglobin was refined at 2.5 A resolution. The chimera subunit was constructed by replacing an exon-encoded module M4 of the beta-subunit with that of the alpha-subunit, simulating an exon-shuffling event. The implanted module M4 retained the native alpha-subunit structure, while module M3 was disturbed around the site where a new type of intron was recently found. Some of the residues were found in alternative conformations that avoid steric hindrance at the subunit interface. The modules are modestly rigid in their backbone structures by using side-chains to compensate for interface incompatibility.
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{{ABSTRACT_PUBMED_10080899}}
==About this Structure==
==About this Structure==
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[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
[[Category: Respiratory protein]]
[[Category: Respiratory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:44:36 2008''

Revision as of 17:44, 30 June 2008

Image:1ch4.png

Template:STRUCTURE 1ch4

MODULE-SUBSTITUTED CHIMERA HEMOGLOBIN BETA-ALPHA (F133V)

Template:ABSTRACT PUBMED 10080899

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a protein with an artificial exon-shuffling, module M4-substituted chimera hemoglobin beta alpha, at 2.5 A resolution., Shirai T, Fujikake M, Yamane T, Inaba K, Ishimori K, Morishima I, J Mol Biol. 1999 Mar 26;287(2):369-82. PMID:10080899

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