1chn

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{{STRUCTURE_1chn| PDB=1chn | SCENE= }}
{{STRUCTURE_1chn| PDB=1chn | SCENE= }}
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'''MAGNESIUM BINDING TO THE BACTERIAL CHEMOTAXIS PROTEIN CHEY RESULTS IN LARGE CONFORMATIONAL CHANGES INVOLVING ITS FUNCTIONAL SURFACE'''
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===MAGNESIUM BINDING TO THE BACTERIAL CHEMOTAXIS PROTEIN CHEY RESULTS IN LARGE CONFORMATIONAL CHANGES INVOLVING ITS FUNCTIONAL SURFACE===
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==Overview==
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The three-dimensional crystal structure of the bacterial chemotaxis protein CheY with the essential Mg2+ cation bound to the active site reveals large conformational changes caused by the metal binding. Displacements of up to 10 A are observed in several residues at the N terminus of alpha-helix 4 and in the preceding loop. One turn of this helix unwinds, and an Asn residue that was located inside the helix becomes the new N-cap. This supports the important role that N or C-cap residues play in alpha-helix stability. In addition the preceding beta-strand becomes elongated and a new beta-turn appears. The final effect is a significant modification of the surface relief of the protein in a region previously indicated, by genetic analysis, to be essential for CheY function. It is suggested that binding of a divalent cation to CheY could play a significant part in CheY activation and consequently in signal transduction in prokaryotes.
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{{ABSTRACT_PUBMED_8176739}}
==About this Structure==
==About this Structure==
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[[Category: Coll, M.]]
[[Category: Coll, M.]]
[[Category: Signal transduction protein]]
[[Category: Signal transduction protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:44:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:45:29 2008''

Revision as of 17:45, 30 June 2008

Image:1chn.png

Template:STRUCTURE 1chn

MAGNESIUM BINDING TO THE BACTERIAL CHEMOTAXIS PROTEIN CHEY RESULTS IN LARGE CONFORMATIONAL CHANGES INVOLVING ITS FUNCTIONAL SURFACE

Template:ABSTRACT PUBMED 8176739

About this Structure

1CHN is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Magnesium binding to the bacterial chemotaxis protein CheY results in large conformational changes involving its functional surface., Bellsolell L, Prieto J, Serrano L, Coll M, J Mol Biol. 1994 May 13;238(4):489-95. PMID:8176739

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