1chr

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{{STRUCTURE_1chr| PDB=1chr | SCENE= }}
{{STRUCTURE_1chr| PDB=1chr | SCENE= }}
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'''CRYSTAL STRUCTURE OF CHLOROMUCONATE CYCLOISOMERASE FROM ALCALIGENES EUTROPHUS JMP134 (PJP4) AT 3 ANGSTROMS RESOLUTION'''
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===CRYSTAL STRUCTURE OF CHLOROMUCONATE CYCLOISOMERASE FROM ALCALIGENES EUTROPHUS JMP134 (PJP4) AT 3 ANGSTROMS RESOLUTION===
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==Overview==
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Chloromuconate cycloisomerase (E.C. 5.5.1.7) is an enzyme involved in the 2,4-dichlorophenoxyacetate degradation pathway of Alcaligenes eutrophus JMP134 (pJP4). The crystal structure of this protein was determined at 3 A resolution by molecular-replacement techniques using atomic coordinates from the reported crystal structure of the homologous muconate cycloisomerase (E.C. 5.5.1.1) from Pseudomonas putida as the search model (42% identical positions in the sequences). Structure refinement by simulated-annealing and restrained least-squares techniques converged at R = 0.195. In the crystals studied, space group I4, the protein is present as two octamers per unit cell with two subunits per asymmetric unit. Each subunit consists of two globular domains, one of which forms an alpha/beta-barrel. Comparison of this structure with that of muconate cycloisomerase reveals the reasons for the altered substrate specificity of chloromuconate cycloisomerase. Marked differences are observed in polarity, accessibility and hydrogen-bonding potential in the channel leading into the active site as well as in the active center itself.
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==About this Structure==
==About this Structure==
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[[Category: Stezowski, J J.]]
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[[Category: Isomerase]]
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Revision as of 17:45, 30 June 2008

Image:1chr.png

Template:STRUCTURE 1chr

CRYSTAL STRUCTURE OF CHLOROMUCONATE CYCLOISOMERASE FROM ALCALIGENES EUTROPHUS JMP134 (PJP4) AT 3 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 15299479

About this Structure

1CHR is a Single protein structure of sequence from Cupriavidus necator. Full crystallographic information is available from OCA.

Reference

Crystal structure of chloromuconate cycloisomerase from Alcaligenes eutrophus JMP134 (pJP4) at 3 A resolution., Hoier H, Schlomann M, Hammer A, Glusker JP, Carrell HL, Goldman A, Stezowski JJ, Heinemann U, Acta Crystallogr D Biol Crystallogr. 1994 Jan 1;50(Pt 1):75-84. PMID:15299479

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