1cit

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{{STRUCTURE_1cit| PDB=1cit | SCENE= }}
{{STRUCTURE_1cit| PDB=1cit | SCENE= }}
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'''DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B'''
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===DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B===
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==Overview==
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The 2.7 A X-ray crystal structure of the DNA-binding domain (DBD) of the orphan nuclear receptor, nerve growth factor-induced-B (NGFI-B), complexed to its high-affinity DNA target, represents the first structure analysis of a nuclear receptor DBD bound as a monomer to DNA. The structure of the core DBD and its interactions with the major groove of the DNA are similar to previously crystallographically solved DBD-DNA complexes in this superfamily; however, residues C-terminal to this core form a separate and unique substructure that interacts extensively and in a sequence-specific way with the minor groove of its DNA target, in particular with the characteristic 3 A-T base-pair identity element that extends 5' to the usual nuclear receptor half-site (AGGTCA).
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The line below this paragraph, {{ABSTRACT_PUBMED_10331876}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10331876 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10331876}}
==About this Structure==
==About this Structure==
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[[Category: Protein/dna]]
[[Category: Protein/dna]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:46:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:48:16 2008''

Revision as of 17:48, 30 June 2008

Image:1cit.png

Template:STRUCTURE 1cit

DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B

Template:ABSTRACT PUBMED 10331876

About this Structure

1CIT is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B., Meinke G, Sigler PB, Nat Struct Biol. 1999 May;6(5):471-7. PMID:10331876

Page seeded by OCA on Mon Jun 30 20:48:16 2008

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