1cjy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1cjy.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1cjy.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1cjy| PDB=1cjy | SCENE= }}
{{STRUCTURE_1cjy| PDB=1cjy | SCENE= }}
-
'''HUMAN CYTOSOLIC PHOSPHOLIPASE A2'''
+
===HUMAN CYTOSOLIC PHOSPHOLIPASE A2===
-
==Overview==
+
<!--
-
Cytosolic phospholipase A2 initiates the biosynthesis of prostaglandins, leukotrienes, and platelet-activating factor (PAF), mediators of the pathophysiology of asthma and arthritis. Here, we report the X-ray crystal structure of human cPLA2 at 2.5 A. cPLA2 consists of an N-terminal calcium-dependent lipid-binding/C2 domain and a catalytic unit whose topology is distinct from that of other lipases. An unusual Ser-Asp dyad located in a deep cleft at the center of a predominantly hydrophobic funnel selectively cleaves arachidonyl phospholipids. The structure reveals a flexible lid that must move to allow substrate access to the active site, thus explaining the interfacial activation of this important lipase.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10319815}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10319815 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10319815}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Lipid-binding]]
[[Category: Lipid-binding]]
[[Category: Phospholipase]]
[[Category: Phospholipase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:48:56 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:51:08 2008''

Revision as of 17:51, 30 June 2008

Image:1cjy.png

Template:STRUCTURE 1cjy

HUMAN CYTOSOLIC PHOSPHOLIPASE A2

Template:ABSTRACT PUBMED 10319815

About this Structure

1CJY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism., Dessen A, Tang J, Schmidt H, Stahl M, Clark JD, Seehra J, Somers WS, Cell. 1999 Apr 30;97(3):349-60. PMID:10319815

Page seeded by OCA on Mon Jun 30 20:51:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1cjy"
Personal tools