1ck1

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{{STRUCTURE_1ck1| PDB=1ck1 | SCENE= }}
{{STRUCTURE_1ck1| PDB=1ck1 | SCENE= }}
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'''STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN C3'''
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===STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN C3===
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==Overview==
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Staphylococcal enterotoxins are superantigen exotoxins that mediate food poisoning and toxic shock syndrome in humans. Despite their structural and functional similarities, superantigens display subtle differences in biological properties and modes of receptor binding as a result of zinc atoms bound differently in their crystal structures. For example, the crystal structures of the staphylococcal enterotoxins in the type C serogroup (SECs) contain a zinc atom coordinated by one aspartate and two histidine residues from one molecule and another aspartate residue from the next molecule, thus forming a dimer. This type of zinc ligation and zinc-mediated dimerization occurs in several SECs, but not in most other staphylococcal enterotoxin serogroups. This prompted us to investigate the potential importance of zinc in SEC-mediated pathogenesis. Site-directed mutagenesis was used to replace SEC zinc binding ligands with alanine. SEC mutants unable to bind zinc did not have major conformational alterations although they failed to form dimers. Zinc binding was not essential for T cell stimulation, emesis, or lethality although in general the mutants were less pyrogenic. Thus the zinc atom in SECs might represent a non-functional heavy atom in an exotoxin group that has diverged from related bacterial toxins containing crucial zinc atoms.
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(as it appears on PubMed at http://www.pubmed.gov), where 11934896 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11934896}}
==About this Structure==
==About this Structure==
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[[Category: Superantigen]]
[[Category: Superantigen]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:49:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:51:23 2008''

Revision as of 17:51, 30 June 2008

Image:1ck1.png

Template:STRUCTURE 1ck1

STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN C3

Template:ABSTRACT PUBMED 11934896

About this Structure

1CK1 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Zinc-mediated dimerization and its effect on activity and conformation of staphylococcal enterotoxin type C., Chi YI, Sadler I, Jablonski LM, Callantine SD, Deobald CF, Stauffacher CV, Bohach GA, J Biol Chem. 2002 Jun 21;277(25):22839-46. Epub 2002 Apr 4. PMID:11934896

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