1cl7

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{{STRUCTURE_1cl7| PDB=1cl7 | SCENE= }}
{{STRUCTURE_1cl7| PDB=1cl7 | SCENE= }}
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'''ANTI HIV1 PROTEASE FAB'''
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===ANTI HIV1 PROTEASE FAB===
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==Overview==
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The monoclonal antibody 1696, directed against the HIV-1 protease, displays strong inhibitory effects toward the catalytic activity of the enzyme of both the HIV-1 and HIV-2 isolates. This antibody cross-reacts with peptides that include the N-terminus of the enzyme, a region that is well conserved in sequence among different viral strains and which, furthermore, is crucial for homodimerization to the active enzymatic form. This observation, as well as antigen-binding studies in the presence of an active site inhibitor, suggest that 1696 inhibits the HIV protease by destabilizing its active homodimeric form. To characterize further how the antibody 1696 inhibits the HIV-1 and HIV-2 proteases, we have solved the crystal structure of its Fab fragment by molecular replacement and refined it at 3.0 A resolution. The antigen binding site has a deep cavity at its center, which is lined mainly by acidic and hydrophobic residues, and is large enough to accommodate several antigen residues. The structure of the Fab 1696 could form a starting basis for the design of alternative HIV protease-inhibiting molecules of broad specificity.
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{{ABSTRACT_PUBMED_10631984}}
==About this Structure==
==About this Structure==
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[[Category: Hiv1 protease]]
[[Category: Hiv1 protease]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:51:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:54:11 2008''

Revision as of 17:54, 30 June 2008

Image:1cl7.png

Template:STRUCTURE 1cl7

ANTI HIV1 PROTEASE FAB

Template:ABSTRACT PUBMED 10631984

About this Structure

1CL7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Inhibition of the HIV-1 and HIV-2 proteases by a monoclonal antibody., Lescar J, Brynda J, Rezacova P, Stouracova R, Riottot MM, Chitarra V, Fabry M, Horejsi M, Sedlacek J, Bentley GA, Protein Sci. 1999 Dec;8(12):2686-96. PMID:10631984

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