1cmv

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[[Image:1cmv.gif|left|200px]]
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{{STRUCTURE_1cmv| PDB=1cmv | SCENE= }}
{{STRUCTURE_1cmv| PDB=1cmv | SCENE= }}
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'''HUMAN CYTOMEGALOVIRUS PROTEASE'''
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===HUMAN CYTOMEGALOVIRUS PROTEASE===
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==Overview==
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Herpesviruses encode a serine protease that specifically cleaves assembly protein. This protease is critical for replication, and represents a new target for antiviral drug design. Here we report the three-dimensional structure of the protease from human cytomegalovirus (hCMV) at 2.27 angstroms resolution. The structure reveals a unique fold and new catalytic strategy for cleavage. The monomer fold of the enzyme, a seven-stranded beta-barrel encircled by a chain of helices that form the carboxy terminus of the molecule, is unrelated to those observed in classic serine proteases such as chymotrypsin and subtilisin. The serine nucleophile at position 132 is activated by two juxtaposed histidine residues at positions 63 and 157. Dimerization, which seems to be necessary for activity, is observed in the crystals. Correlations of the structure with the sequences of herpesvirus proteases suggest that dimerization may confer specificity and recognition in substrate binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 8805708 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8805708}}
==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:57:58 2008''

Revision as of 17:58, 30 June 2008

Image:1cmv.png

Template:STRUCTURE 1cmv

HUMAN CYTOMEGALOVIRUS PROTEASE

Template:ABSTRACT PUBMED 8805708

About this Structure

1CMV is a Single protein structure of sequence from Human herpesvirus 5. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of human cytomegalovirus protease., Shieh HS, Kurumbail RG, Stevens AM, Stegeman RA, Sturman EJ, Pak JY, Wittwer AJ, Palmier MO, Wiegand RC, Holwerda BC, Stallings WC, Nature. 1996 Sep 19;383(6597):279-82. PMID:8805708

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