1cn0

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{{Seed}}
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{{STRUCTURE_1cn0| PDB=1cn0 | SCENE= }}
{{STRUCTURE_1cn0| PDB=1cn0 | SCENE= }}
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'''CRYSTAL STRUCTURE OF D(ACCCT)'''
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===CRYSTAL STRUCTURE OF D(ACCCT)===
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==Overview==
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The crystal structure of d(ACCCT), solved by molecular replacement, shows a four-stranded i-motif conformation, where two parallel duplexes intercalate with one another in opposite orientations. Each duplex is stabilized by hemi-protonated C-C+ base pairing between parallel strands, and a string of water molecules bridge the cytosine N4 atoms to phosphate O atoms. This structure of d(ACCCT) shows examples of reversed Hoogsteen and Watson-Crick base pairing in both intermolecular and intramolecular manners to stabilize the tetraplex. Noticeably, the four-stranded complex is further stabilized at one end by a three-base hydrogen-bonding network, in which two adenines and a thymine form four hydrogen bonds via a reverse Hoogsteen and an asymmetric adenine-adenine base pairing. The structure of d(ACCCT) shows a similar local structure to that found in the d(TAA) part of the crystal structure of d(TAACCC) and provides further structural evidence that these base arrangements are essential for stabilizing these novel DNA super-secondary structures.
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The line below this paragraph, {{ABSTRACT_PUBMED_10089350}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10089350 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10089350}}
==About this Structure==
==About this Structure==
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[[Category: I-motif]]
[[Category: I-motif]]
[[Category: Telomere]]
[[Category: Telomere]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:54:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:58:18 2008''

Revision as of 17:58, 30 June 2008

Image:1cn0.png

Template:STRUCTURE 1cn0

CRYSTAL STRUCTURE OF D(ACCCT)

Template:ABSTRACT PUBMED 10089350

About this Structure

Full crystallographic information is available from OCA.

Reference

Stabilization of the i-motif by intramolecular adenine-adenine-thymine base triple in the structure of d(ACCCT)., Weil J, Min T, Yang C, Wang S, Sutherland C, Sinha N, Kang C, Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):422-9. PMID:10089350

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