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1cmz

From Proteopedia

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[[Image:1cmz.gif|left|200px]]
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{{STRUCTURE_1cmz| PDB=1cmz | SCENE= }}
{{STRUCTURE_1cmz| PDB=1cmz | SCENE= }}
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'''SOLUTION STRUCTURE OF GAIP (GALPHA INTERACTING PROTEIN): A REGULATOR OF G PROTEIN SIGNALING'''
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===SOLUTION STRUCTURE OF GAIP (GALPHA INTERACTING PROTEIN): A REGULATOR OF G PROTEIN SIGNALING===
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==Overview==
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The solution structure of the human protein GAIP (Galpha interacting protein), a regulator of G protein signaling, has been determined by NMR techniques. Dipolar couplings of the oriented protein in two different liquid crystal media have been used in the structure calculation. The solution structure of GAIP is compared to the crystal structure of an homologous protein from rat (RGS4) complexed to the alpha-subunit of a G protein. Some of RGS4 residues involved in the Galpha-RGS binding interface have similar orientations in GAIP (free form), indicating that upon binding these residues do not suffer conformational rearrangements, and therefore, their role does not seem to be restricted to Galpha interaction but also to RGS folding and stability. We suggest that other structural differences between the two proteins may be related to the process of binding as well as to a distinct efficiency in their respective GTPase activating function.
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(as it appears on PubMed at http://www.pubmed.gov), where 10452897 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10452897}}
==About this Structure==
==About this Structure==
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1CMZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMZ OCA].
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1CMZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMZ OCA].
==Reference==
==Reference==
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[[Category: Regulator of g protein]]
[[Category: Regulator of g protein]]
[[Category: Rg]]
[[Category: Rg]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:54:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:58:19 2008''

Revision as of 17:58, 30 June 2008

Image:1cmz.png

Template:STRUCTURE 1cmz

SOLUTION STRUCTURE OF GAIP (GALPHA INTERACTING PROTEIN): A REGULATOR OF G PROTEIN SIGNALING

Template:ABSTRACT PUBMED 10452897

About this Structure

1CMZ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling., de Alba E, De Vries L, Farquhar MG, Tjandra N, J Mol Biol. 1999 Aug 27;291(4):927-39. PMID:10452897

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